Syncope Secondary to Concomitant Ingestion of Tizanidine and Alcohol in a Patient With Alcohol Use Disorder

Syncope is the transient loss of consciousness due to cerebral hypoperfusion. A significant number of individuals experience a syncopal attack at one stage of their lives. The common causes of syncope include vasovagal syncope, orthostatic hypotension, and cardiac causes. Drugs are also associated w...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e57249
Main Authors: Forsah, Sabastain F, Ugwendum, Derek, Arrey Agbor, Divine Besong, Ndema, Nancelle, Ndemazie, Nkafu Bechem, Kankeu Tonpouwo, Gauvain, Taylor, Akua Aboah A, Fuoching, Nkeng, James-Gregory, Davene, Amoah, Shannia, Arulthasan, Vaithilingam, Nfonoyim, Jay
Format: Article
Language:English
Subjects:
Alcohol use
Alcohol withdrawal
Alcoholism
Blood pressure
Cardiac arrhythmia
Cardiac stress tests
Cardiology
Case reports
Coma
Consciousness
Drug dosages
Drug withdrawal
Electrocardiography
Emergency medical care
Fainting
Internal Medicine
Kinases
Laboratories
Mortality
Nervous system
Neurology
Orthostatic hypotension
Patients
Posture
Toxicity
Vital signs
Vitamin B
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Summary:Syncope is the transient loss of consciousness due to cerebral hypoperfusion. A significant number of individuals experience a syncopal attack at one stage of their lives. The common causes of syncope include vasovagal syncope, orthostatic hypotension, and cardiac causes. Drugs are also associated with causing syncope. The drugs involved are mostly those that depress the central nervous system, and concomitant use of more than one of such drugs increases the risk of syncope even further. Tizanidine and alcohol individually can cause hypotension and combining both drugs is not advised due to heightened central nervous system depression and profound hypotension. We present a case of a 53-year-old female with alcohol use disorder who presented with a first-time syncopal attack due to postural hypotension after ingesting both tizanidine and alcohol concurrently. Co-administration of tizanidine and alcohol is not advised, however, cases of syncope have been rarely reported with concomitant use. This case will enlighten physicians to counsel patients about the need to abstain from alcohol consumption when taking tizanidine.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.57249