The Role of Radiotherapy for Meningeal Melanocytomas - A 20 Year Update

Meningeal melanocytomas are rare tumors of the central nervous system and optimal treatment needs further clarification. This study compared subtotal resection (STR), STR plus radiation therapy (RT), gross total resection (GTR), and GTR+RT to better define the role of postoperative RT. All cases rep...

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Bibliographic Details
Published in:In vivo (Athens) 2024-05, Vol.38 (3), p.1220-1228
Main Authors: Rades, Dirk, Zemskova, Oksana, Gliemroth, Jan, Yu, Nathan Y
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Combined Modality Therapy
Female
Humans
Male
Melanoma - mortality
Melanoma - pathology
Melanoma - radiotherapy
Meningeal Neoplasms - mortality
Meningeal Neoplasms - pathology
Meningeal Neoplasms - radiotherapy
Middle Aged
Treatment Outcome
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Summary:Meningeal melanocytomas are rare tumors of the central nervous system and optimal treatment needs further clarification. This study compared subtotal resection (STR), STR plus radiation therapy (RT), gross total resection (GTR), and GTR+RT to better define the role of postoperative RT. All cases reported in the literature were reviewed. Patients (n=184) with complete data were analyzed for local control (LC) and overall survival (OS). On univariate analysis, GTR (vs. STR) was associated with improved LC (p=0.016). When comparing the treatment regimens, best and worst results were found after GTR+RT and STR alone, respectively (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.13558