Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas

Maintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing proc...

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Bibliographic Details
Published in:The ocular surface 2023-10, Vol.30, p.85-91
Main Authors: Segars, Kristen L., Trinkaus-Randall, Vickery
Format: Article
Language:English
Subjects:
Cornea
Cornea - metabolism
Corneal construct
Corneal Stroma - pathology
Glycosaminoglycan
Glycosaminoglycans - metabolism
Injury response
Proteoglycan
Proteoglycans - metabolism
Stroma
Wound Healing - physiology
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Summary:Maintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing process and in pathological conditions resulting in corneal opacity. Understanding these changes has been essential for the development of corneal prostheses and corneal reconstruction. The goal of this review article is to summarize and consolidate research in the alterations seen in glycosaminoglycans in injured and hypoxic states, address the role of proteins that can regulate glycosaminoglycans in the corneal wound healing process, and apply these findings to the context of corneal restoration through reconstruction or the insertion of synthetic devices.
ISSN:1542-0124
1937-5913
DOI:10.1016/j.jtos.2023.08.008