Evaluating the Efficacy of Antioxidant Therapy in Enhancing the Quality of Life of Chronic Pancreatitis Patients: A Systematic Review

Chronic pancreatitis (CP), an inflammatory disease characterized by irreversible pancreatic changes and progressive fibrosis, significantly impairs patients' quality of life. This systematic review aims to assess the efficacy of antioxidant therapy in enhancing the quality of life of CP patient...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-04, Vol.16 (4), p.e57402-e57402
Main Authors: Al Balushi, Hamza, Ahmed, Junaid, Ahuja, Laksh Kumar, Barkha, Fnu, Shafeeq, Mohamed Ishraq, Baluch, Amna B, Altinkaynak, Yahya, Abdallah, Shenouda, Islam, Hamza, Islam, Rabia, Rehman, Abdur, Shehryar, Abdullah, Raza, Ali
Format: Article
Language:English
Subjects:
Antioxidants
Cohort analysis
Data analysis
Gastroenterology
Internal Medicine
Observational studies
Oxidative stress
Pain management
Pancreatitis
Pathology
Patients
Quality of life
Search strategies
Systematic review
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Summary:Chronic pancreatitis (CP), an inflammatory disease characterized by irreversible pancreatic changes and progressive fibrosis, significantly impairs patients' quality of life. This systematic review aims to assess the efficacy of antioxidant therapy in enhancing the quality of life of CP patients. Focusing on the role of oxidative stress in CP pathogenesis, we explored several databases for studies evaluating the impact of antioxidant supplementation. The review included randomized controlled trials and cohort studies reporting pain frequency, intensity, and overall quality of life measures. Findings from these studies present a mixed view of the efficacy of antioxidants in CP, with some suggesting benefits in symptom management, while others show inconsistency in improving patient outcomes. The review concludes that while antioxidant therapy holds potential, especially in symptom alleviation, there is a need for more rigorous, larger-scale studies to confirm its effectiveness in CP management and to establish standardized treatment protocols. The incorporation of antioxidants into CP treatment plans should be approached with personalized care, considering the varied responses observed in different patient populations.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.57402