The STK38–XPO1 axis, a new actor in physiology and cancer

The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth. Here,...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2021-03, Vol.78 (5), p.1943-1955
Main Authors: Martin, Alexandre PJ, Aushev, Vasily N., Zalcman, Gérard, Camonis, Jacques H.
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Beclin-1 - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cell death
Cell differentiation
Cell Nucleus - metabolism
Cell proliferation
Exportin 1 Protein
Exports
Humans
Karyopherins - metabolism
Kinases
Life Sciences
Neoplasms - metabolism
Nuclear transport
Phosphorylation
Protein Serine-Threonine Kinases - metabolism
Receptors, Cytoplasmic and Nuclear - metabolism
Regulators
Review
Signal Transduction
Tumor suppressor genes
Yes-associated protein
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Summary:The Hippo signal transduction pathway is an essential regulator of organ size during developmental growth by controlling multiple cellular processes such as cell proliferation, cell death, differentiation, and stemness. Dysfunctional Hippo signaling pathway leads to dramatic tissue overgrowth. Here, we will briefly introduce the Hippo tumor suppressor pathway before focusing on one of its members and the unexpected twists that followed our quest of its functions in its multifarious actions beside the Hippo pathway: the STK38 kinase. In this review, we will precisely discuss the newly identified role of STK38 on regulating the nuclear export machinery by phosphorylating and activating, the major nuclear export receptor XPO1. Finally, we will phrase STK38′s role on regulating the subcellular distribution of crucial cellular regulators such as Beclin1 and YAP1 with its implication in cancer.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-020-03690-w