Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment

Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2021-01, Vol.78 (1), p.79-91
Main Authors: Esmaeili, Abazar, Hosseini, Samaneh, Baghaban Eslaminejad, Mohamadreza
Format: Article
Language:English
Subjects:
Arthritis
Biochemistry
Biomedical and Life Sciences
Biomedical materials
Biomedicine
Cartilage
Cartilage - physiology
Cartilage diseases
Cell Biology
Cell Differentiation
Chondrocytes - cytology
Chondrocytes - metabolism
Electroporation
Extracellular vesicles
Extracellular Vesicles - chemistry
Extracellular Vesicles - metabolism
Gene expression
Health services
Homeostasis
Humans
Life Sciences
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
MicroRNAs
MicroRNAs - chemistry
MicroRNAs - metabolism
MicroRNAs - therapeutic use
miRNA
Osteoarthritis
Osteoarthritis - drug therapy
Osteoarthritis - genetics
Osteoarthritis - pathology
Regeneration
Review
Ribonucleic acid
RNA
Tissue engineering
Vesicles
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Summary:Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-020-03585-w