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Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment
Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the...
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| Published in: | Cellular and molecular life sciences : CMLS 2021-01, Vol.78 (1), p.79-91 |
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| creator | Esmaeili, Abazar Hosseini, Samaneh Baghaban Eslaminejad, Mohamadreza |
| description | Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications. |
| doi_str_mv | 10.1007/s00018-020-03585-w |
| format | article |
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In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-020-03585-w</identifier><identifier>PMID: 32601714</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Arthritis ; Biochemistry ; Biomedical and Life Sciences ; Biomedical materials ; Biomedicine ; Cartilage ; Cartilage - physiology ; Cartilage diseases ; Cell Biology ; Cell Differentiation ; Chondrocytes - cytology ; Chondrocytes - metabolism ; Electroporation ; Extracellular vesicles ; Extracellular Vesicles - chemistry ; Extracellular Vesicles - metabolism ; Gene expression ; Health services ; Homeostasis ; Humans ; Life Sciences ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; MicroRNAs ; MicroRNAs - chemistry ; MicroRNAs - metabolism ; MicroRNAs - therapeutic use ; miRNA ; Osteoarthritis ; Osteoarthritis - drug therapy ; Osteoarthritis - genetics ; Osteoarthritis - pathology ; Regeneration ; Review ; Ribonucleic acid ; RNA ; Tissue engineering ; Vesicles</subject><ispartof>Cellular and molecular life sciences : CMLS, 2021-01, Vol.78 (1), p.79-91</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-c2ddf8539d878c70a7e3fd664886b2337a639c5d2e27a00dcd9322a5720228c53</citedby><cites>FETCH-LOGICAL-c497t-c2ddf8539d878c70a7e3fd664886b2337a639c5d2e27a00dcd9322a5720228c53</cites><orcidid>0000-0002-1036-0072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11072722/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11072722/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32601714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esmaeili, Abazar</creatorcontrib><creatorcontrib>Hosseini, Samaneh</creatorcontrib><creatorcontrib>Baghaban Eslaminejad, Mohamadreza</creatorcontrib><title>Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications.</description><subject>Arthritis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Cartilage</subject><subject>Cartilage - physiology</subject><subject>Cartilage diseases</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Chondrocytes - cytology</subject><subject>Chondrocytes - metabolism</subject><subject>Electroporation</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - chemistry</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Gene expression</subject><subject>Health services</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>MicroRNAs</subject><subject>MicroRNAs - chemistry</subject><subject>MicroRNAs - metabolism</subject><subject>MicroRNAs - therapeutic use</subject><subject>miRNA</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarthritis - genetics</subject><subject>Osteoarthritis - pathology</subject><subject>Regeneration</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Tissue engineering</subject><subject>Vesicles</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi0Eoh_wBzigSFx6CYzHSeycUFUVilSBhEDiZrn2ZOtVEi-2s6X_Hre7lI8DkiV_zDPveOZl7AWH1xxAvkkAwFUNCDWIVrX1zSN2yJty7UHyx_tzp_DbATtKaV3oVmH3lB0I7IBL3hyy9fm88jNRJFfTjxyNpXFcRhOrLSVvR0qVKWuuwib7yafsbZVDGKshxGryNobPH08rR6PfUry9fw0pUzAxX0effapyJJMnmvMz9mQwY6Ln-_2YfX13_uXsor789P7D2ellbZte5tqic4NqRe-UVFaCkSQG13WNUt0VCiFNJ3rbOiSUBsBZ1wtE00oERGVbccze7nQ3y9VEzpbS0Yx6E_1k4q0Oxuu_I7O_1quw1ZyDRIlYFE72CjF8XyhlXTq_G4yZKSxJY8N7UI3kXUFf_YOuwxLn0l-hVKeUaLksFO6oMq-UIg0Pv-Gg77zUOy918VLfe6lvStLLP_t4SPllXgHEDkglNK8o_q79H9mfy1Osxw</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Esmaeili, Abazar</creator><creator>Hosseini, Samaneh</creator><creator>Baghaban Eslaminejad, Mohamadreza</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1036-0072</orcidid></search><sort><creationdate>20210101</creationdate><title>Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment</title><author>Esmaeili, Abazar ; Hosseini, Samaneh ; Baghaban Eslaminejad, Mohamadreza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-c2ddf8539d878c70a7e3fd664886b2337a639c5d2e27a00dcd9322a5720228c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Arthritis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical materials</topic><topic>Biomedicine</topic><topic>Cartilage</topic><topic>Cartilage - physiology</topic><topic>Cartilage diseases</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Chondrocytes - cytology</topic><topic>Chondrocytes - metabolism</topic><topic>Electroporation</topic><topic>Extracellular vesicles</topic><topic>Extracellular Vesicles - chemistry</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Gene expression</topic><topic>Health services</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>MicroRNAs</topic><topic>MicroRNAs - chemistry</topic><topic>MicroRNAs - metabolism</topic><topic>MicroRNAs - therapeutic use</topic><topic>miRNA</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - drug therapy</topic><topic>Osteoarthritis - genetics</topic><topic>Osteoarthritis - pathology</topic><topic>Regeneration</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Tissue engineering</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esmaeili, Abazar</creatorcontrib><creatorcontrib>Hosseini, Samaneh</creatorcontrib><creatorcontrib>Baghaban Eslaminejad, Mohamadreza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>78</volume><issue>1</issue><spage>79</spage><epage>91</epage><pages>79-91</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32601714</pmid><doi>10.1007/s00018-020-03585-w</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1036-0072</orcidid></addata></record> |
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| subjects | Arthritis Biochemistry Biomedical and Life Sciences Biomedical materials Biomedicine Cartilage Cartilage - physiology Cartilage diseases Cell Biology Cell Differentiation Chondrocytes - cytology Chondrocytes - metabolism Electroporation Extracellular vesicles Extracellular Vesicles - chemistry Extracellular Vesicles - metabolism Gene expression Health services Homeostasis Humans Life Sciences Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism MicroRNAs MicroRNAs - chemistry MicroRNAs - metabolism MicroRNAs - therapeutic use miRNA Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - pathology Regeneration Review Ribonucleic acid RNA Tissue engineering Vesicles |
| title | Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment |
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