Structure and function of adenosine receptor heteromers

Adenosine is one of the most ancient signaling molecules and has receptors in both animals and plants. In mammals there are four specific receptors, A 1 , A 2A , A 2B , and A 3 , which belong to the superfamily of G-protein-coupled receptors (GPCRs). Evidence accumulated in the last 20 years indicat...

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Published in:Cellular and molecular life sciences : CMLS 2021-04, Vol.78 (8), p.3957-3968
Main Authors: Franco, Rafael, Cordomí, Arnau, Llinas del Torrent, Claudia, Lillo, Alejandro, Serrano-Marín, Joan, Navarro, Gemma, Pardo, Leonardo
Format: Article
Language:English
Subjects:
Adenosine
Adenosine - metabolism
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
G protein-coupled receptors
Humans
Life Sciences
Models, Molecular
Protein Conformation
Protein Multimerization
Receptors
Receptors, Purinergic P1 - chemistry
Receptors, Purinergic P1 - metabolism
Review
Signal Transduction
Signaling
Structure-function relationships
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Summary:Adenosine is one of the most ancient signaling molecules and has receptors in both animals and plants. In mammals there are four specific receptors, A 1 , A 2A , A 2B , and A 3 , which belong to the superfamily of G-protein-coupled receptors (GPCRs). Evidence accumulated in the last 20 years indicates that GPCRs are often expressed as oligomeric complexes formed by a number of equal (homomers) or different (heteromers) receptors. This review presents the data showing the occurrence of heteromers formed by A 1 and A 2A , A 2A and A 2B , and A 2A and A 3 receptors highlighting (i) their tetrameric structural arrangements, and (ii) the functional diversity that those heteromers provide to adenosinergic signaling.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-021-03761-6