Noncoding RNAs in tumor metastasis: molecular and clinical perspectives

Metastasis is the main culprit of cancer-associated mortality and involves a complex and multistage process termed the metastatic cascade, which requires tumor cells to detach from the primary site, intravasate, disseminate in the circulation, extravasate, adapt to the foreign microenvironment, and...

Full description

Saved in:
Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2021-11, Vol.78 (21-22), p.6823-6850
Main Authors: Liu, Qiu-Luo, Zhang, Zhe, Wei, Xiawei, Zhou, Zong-Guang
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Extravasation
Humans
Life Sciences
Metastases
Metastasis
Microenvironments
Molecular modelling
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasms - genetics
Neoplasms - pathology
Non-coding RNA
Proteins
Review
RNA, Untranslated - genetics
Therapeutic applications
Tumor cells
Tumor Microenvironment - genetics
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metastasis is the main culprit of cancer-associated mortality and involves a complex and multistage process termed the metastatic cascade, which requires tumor cells to detach from the primary site, intravasate, disseminate in the circulation, extravasate, adapt to the foreign microenvironment, and form organ-specific colonization. Each of these processes has been already studied extensively for molecular mechanisms focused mainly on protein-coding genes. Recently, increasing evidence is pointing towards RNAs without coding potential for proteins, referred to as non-coding RNAs, as regulators in shaping cellular activity. Since those first reports, the detection and characterization of non-coding RNA have explosively thrived and greatly enriched the understanding of the molecular regulatory networks in metastasis. Moreover, a comprehensive description of ncRNA dysregulation will provide new insights into novel tools for the early detection and treatment of metastatic cancer. In this review, we focus on discussion of the emerging role of ncRNAs in governing cancer metastasis and describe step by step how ncRNAs impinge on cancer metastasis. In particular, we highlight the diagnostic and therapeutic applications of ncRNAs in metastatic cancer.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-021-03929-0