Role of inflammatory microenvironment: potential implications for improved breast cancer nano-targeted therapy

Tumor cells, inflammatory cells and chemical factors work together to mediate complex signaling networks, which forms inflammatory tumor microenvironment (TME). The development of breast cancer is closely related to the functional activities of TME. This review introduces the origins of cancer-relat...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2021-03, Vol.78 (5), p.2105-2129
Main Authors: Lan, Meng, Lu, Wenping, Zou, Tengteng, Li, Lihong, Liu, Fengjie, Cai, Tiange, Cai, Yu
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Bioavailability
Biochemistry
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - blood supply
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cell Biology
Design optimization
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug development
Drug resistance
Drug Resistance, Neoplasm - drug effects
Humans
Inflammation
Inflammation - pathology
Inflammation - prevention & control
Life Sciences
Metastases
Nanoparticles - chemistry
Neovascularization, Pathologic - prevention & control
Review
Therapeutic targets
Tumor cells
Tumor microenvironment
Tumor Microenvironment - drug effects
Tumors
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Summary:Tumor cells, inflammatory cells and chemical factors work together to mediate complex signaling networks, which forms inflammatory tumor microenvironment (TME). The development of breast cancer is closely related to the functional activities of TME. This review introduces the origins of cancer-related chronic inflammation and the main constituents of inflammatory microenvironment. Inflammatory microenvironment plays an important role in breast cancer growth, metastasis, drug resistance and angiogenesis through multifactorial mechanisms. It is suggested that inflammatory microenvironment contributes to providing possible mechanisms of drug action and modes of drug transport for anti-cancer treatment. Nano-drug delivery system (NDDS) becomes a popular topic for optimizing the design of tumor targeting drugs. It is seen that with the development of therapeutic approaches, NDDS can be used to achieve drug-targeted delivery well across the biological barriers and into cells, resulting in superior bioavailability, drug dose reduction as well as off-target side effect elimination. This paper focuses on the review of modulation mechanisms of inflammatory microenvironment and combination with nano-targeted therapeutic strategies, providing a comprehensive basis for further research on breast cancer prevention and control.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-020-03696-4