Emerging strategies for cancer immunoprevention

The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some special circumstances such as in chronic inflammat...

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Bibliographic Details
Published in:Oncogene 2015-12, Vol.34 (50), p.6029-6039
Main Authors: Roeser, J C, Leach, S D, McAllister, F
Format: Article
Language:English
Subjects:
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Apoptosis
Cancer
Cell Biology
Chemoprevention
Dendritic Cells - immunology
Human Genetics
Humans
Immune system
Immunotherapy
Interleukin 1 Receptor Antagonist Protein - physiology
Interleukin-6 - antagonists & inhibitors
Interleukin-8 - antagonists & inhibitors
Internal Medicine
Medicine
Medicine & Public Health
Methods
Monitoring, Immunologic
Neoplasms - immunology
Neoplasms - prevention & control
Oncology
Oncology, Experimental
Prevention
Programmed Cell Death 1 Receptor - physiology
review
STAT3 Transcription Factor - antagonists & inhibitors
T-Lymphocytes, Regulatory - immunology
Th17 Cells - immunology
Tumorigenesis
Tumors
Vaccines
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Description
Summary:The crucial role of the immune system in the formation and progression of tumors has been widely accepted. On one hand, the surveillance role of the immune system plays an important role in endogenous tumor prevention, but on the other hand, in some special circumstances such as in chronic inflammation, the immune system can actually contribute to the formation and progression of tumors. In recent years, there has been an explosion of novel targeted immunotherapies for advanced cancers. In the present manuscript, we explore known and potential various types of cancer prevention strategies and focus on nonvaccine-based cancer preventive strategies targeting the immune system at the early stages of tumorigenesis.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2015.98