Short-term response to anti-VEGF as indicator of visual prognosis in refractory age-related macular degeneration

Background Some patients with neovascular age-related macular degeneration (nAMD) respond insufficiently to anti-VEGF treatment despite maximal monthly intravitreal injections. Their short-term response between injections was investigated for extent and visual prognosis. Subjects/Methods Monocentric...

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Bibliographic Details
Published in:Eye (London) 2024-05, Vol.38 (7), p.1342-1348
Main Authors: Gigon, Anthony, Iskandar, Antonio, Kasser, Sophie, Naso, Sacha, Zola, Marta, Mantel, Irmela
Format: Article
Language:English
Subjects:
692/308/53/2422
692/699/3161/1626
Acuity
Age
Aged
Aged, 80 and over
Angiogenesis Inhibitors - therapeutic use
Artificial intelligence
Atrophy
Bevacizumab - therapeutic use
Epithelium
Female
Humans
Intravitreal Injections
Laboratory Medicine
Macular degeneration
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Ophthalmology
Pharmaceutical Sciences/Technology
Prognosis
Ranibizumab - administration & dosage
Ranibizumab - therapeutic use
Receptors, Vascular Endothelial Growth Factor - therapeutic use
Retrospective Studies
Subretinal Fluid
Surgery
Surgical Oncology
Tomography, Optical Coherence - methods
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Visual Acuity - physiology
Wet Macular Degeneration - diagnosis
Wet Macular Degeneration - drug therapy
Wet Macular Degeneration - physiopathology
Citations: Items that this one cites
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Summary:Background Some patients with neovascular age-related macular degeneration (nAMD) respond insufficiently to anti-VEGF treatment despite maximal monthly intravitreal injections. Their short-term response between injections was investigated for extent and visual prognosis. Subjects/Methods Monocentric retrospective observational study. 45 eyes from 41 patients with refractory nAMD (who previously received at least 12 months of anti-VEGF treatment), evaluated by optical coherence tomography (OCT) in between monthly anti-VEGF injections. The fluid profile on OCT was evaluated before, 1 week after, and 1 month after an intravitreal injection, using central retinal thickness (CRT), manual measurements, and fluid specific volumetric measurements performed by an automated algorithm based on artificial intelligence. Results A significant improvement was found at week 1 in terms of CRT ( p  
ISSN:0950-222X
1476-5454
1476-5454
DOI:10.1038/s41433-023-02900-6