Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson’s Disease: a Comprehensive Review

Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain, KLF4 controls various neurophysiological and neuropathological processes, and its contribution to various neurologic...

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Bibliographic Details
Published in:Molecular neurobiology 2024-06, Vol.61 (6), p.3596-3606
Main Authors: Zamanian, Mohammad Yasin, Golmohammadi, Maryam, Amin, Rana Sherdil, Bustani, Ghadeer Sabah, Romero-Parra, Rosario Mireya, Zabibah, Rahman S., Oz, Tuba, Jalil, Abduladheem Turki, Soltani, Afsaneh, Kujawska, Małgorzata
Format: Article
Language:English
Subjects:
Age
Animals
Apoptosis
Apoptosis - drug effects
Autophagy
Biomedical and Life Sciences
Biomedicine
Brain research
Cell Biology
Disease
Humans
Hydrocephalus
Inflammation
Kinases
KLF4 protein
Krueppel-like factor
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors - metabolism
Literature reviews
Medical laboratories
Molecular modelling
Molecular Targeted Therapy
Movement disorders
Neurobiology
Neurodegenerative diseases
Neurological diseases
Neurology
Neurons
Neurosciences
Nitric oxide
Oxidative stress
Oxidative Stress - drug effects
Parkinson Disease - drug therapy
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
Pathogenesis
Proteins
Stem cells
Therapeutic targets
Toxicology
Transcription factors
Zinc finger proteins
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Summary:Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain, KLF4 controls various neurophysiological and neuropathological processes, and its contribution to various neurological diseases has been widely reported. Parkinson’s disease (PD) is an age-related neurodegenerative disease that might have a connection with KLF4. In this review, we discussed the potential implication of KLF4 in fundamental molecular mechanisms of PD, including aberrant proteostasis, neuroinflammation, apoptosis, oxidative stress, and iron overload. The evidence collected herein sheds new light on KLF4-mediated pathways, which manipulation appears to be a promising therapeutic target for PD management. However, there is a gap in the knowledge on this topic, and extended research is required to understand the translational value of the KLF4-oriented therapeutical approach in PD.
ISSN:0893-7648
1559-1182
1559-1182
DOI:10.1007/s12035-023-03800-2