Plexin B2 tissue expression and related gene polymorphisms in psoriasis and their relation to NB-UVB and Acitretin therapy

• Published in: Archives of Dermatological Research 2024-05, Vol.316 (5), p.162-162, Article 162
• Main Authors: Hegazy, Eisa Mohamed, Taieb, Moustafa A. El, Hassan, Mohammed H., Ibrahim, Ahmed K., El-Din, Ebtehal A., Ibrahim, Hassan M.
• Format: Article
• Language: English
• Subjects: Acitretin - administration & dosage; Acitretin - therapeutic use; Adult; Combined Modality Therapy; Dermatology; Female; Humans; Keratolytic Agents - administration & dosage; Keratolytic Agents - therapeutic use; Male; Medicine; Medicine & Public Health; Middle Aged; Nerve Tissue Proteins - genetics; Original Paper; Polymorphism, Single Nucleotide; Psoriasis - diagnosis; Psoriasis - drug therapy; Psoriasis - genetics; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Immunologic - genetics; Severity of Illness Index; Single-Blind Method; Skin - drug effects; Skin - metabolism; Skin - pathology; Treatment Outcome; Ultraviolet Therapy - methods; Young Adult
• ISSN: 1432-069X; 0340-3696; 1432-069X
• DOI: 10.1007/s00403-024-02880-x

Psoriasis is a chronic, immune-mediated, hyperproliferative skin disease. Etiopathogenesis of psoriasis is not well understood. Plexin B2 was found to have effects on CD100-mediated T-cell morphology and expressed in the immune system. It may play a role in the pathogenesis of psoriasis. To assess the tissue level of plexin-B2 and plexin B2 related gene polymorphism which is signal regulatory protein gamma (SIRPγ-rs71212732) in psoriatic patients before and after NB-UVB, acitretin therapy alone or in combination and to detect correlation between level of tissue plexin B2 and disease severity and improvement. This single blinded randomized controlled trial was carried on 50 psoriatic patients and 50 healthy controls. Psoriasis Area and Severity Index score (PASI) was used to evaluate the disease severity. Tissue plexin-b2 level was measured using ELISA and SIRPγ-rs71212732 (T\C) was assessed using TaqMan™ assays and real-time PCR. A significant lower tissue plexin-B2 level was observed in control group (2.9 ± 0.6 pg/g) than cases (25.8 ± 2.8, pg/g) (p