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Ultrasmall copper nanoclusters as an efficient antibacterial agent for primary peritonitis therapy
The urgent need to develop biocompatible, non-resistant antibacterial agents to effectively combat Gram-negative bacterial infections, particularly for the treatment of peritonitis, presents a significant challenge. In this study, we introduce our water-soluble Cu 30 nanoclusters (NCs) as a potent a...
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Published in: | RSC advances 2024-05, Vol.14 (22), p.15413-15418 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | The urgent need to develop biocompatible, non-resistant antibacterial agents to effectively combat Gram-negative bacterial infections, particularly for the treatment of peritonitis, presents a significant challenge. In this study, we introduce our water-soluble Cu
30
nanoclusters (NCs) as a potent and versatile antibacterial agent tailored for addressing peritonitis. The as-synthesized atomically precise Cu
30
NCs demonstrate exceptional broad-spectrum antibacterial performance, and especially outstanding bactericidal activity of 100% against Gram-negative
Escherichia coli
(
E. coli
). Our
in vivo
experimental findings indicate that the Cu
30
NCs exhibit remarkable therapeutic efficacy against primary peritonitis caused by
E. coli
infection. Specifically, the treatment leads to a profound reduction of drug-resistant bacteria in the peritoneal cavity of mice with peritonitis by more than 5 orders of magnitude, along with the resolution of pathological features in the peritoneum and spleen. Additionally, comprehensive
in vivo
biosafety assessment underscores the remarkable biocompatibility, low biotoxicity, as well as efficient hepatic and renal clearance of Cu
30
NCs, emphasizing their potential for
in vivo
application. This investigation is poised to advance the development of novel Cu NC-based antibacterial agents for
in vivo
antibacterial treatment and the elimination of abdominal inflammation.
An atomically precise copper nanocluster (Cu
30
NC) based antimicrobial agent was synthesized for effective treatment of primary peritonitis. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d4ra01785d |