Bromothiolation of Arynes for the Synthesis of 2‑Bromobenzenethiol Equivalents

A new method to synthesize o-bromobenzenethiol equivalents through aryne intermediates is disclosed. Various o-bromobenzenethiol equivalents are prepared by the bromothiolation of aryne intermediates with potassium xanthates. Aryl xanthates serve in the synthesis of diverse organosulfurs involving p...

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Bibliographic Details
Published in:Organic letters 2024-05, Vol.26 (18), p.3816-3821
Main Authors: Tabata, Shinya, Yoshida, Suguru
Format: Article
Language:English
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Letter
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Summary:A new method to synthesize o-bromobenzenethiol equivalents through aryne intermediates is disclosed. Various o-bromobenzenethiol equivalents are prepared by the bromothiolation of aryne intermediates with potassium xanthates. Aryl xanthates serve in the synthesis of diverse organosulfurs involving phenothiazines and thianthrenes by further transformations.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.4c00944