Rapid Environmental Contamination With Candida auris and Multidrug-Resistant Bacterial Pathogens Near Colonized Patients

• Published in: Clinical infectious diseases 2024-05, Vol.78 (5), p.1276-1284
• Main Authors: Sansom, Sarah E, Gussin, Gabrielle M, Schoeny, Michael, Singh, Raveena D, Adil, Hira, Bell, Pamela, Benson, Ellen C, Bittencourt, Cassiana E, Black, Stephanie, Del Mar Villanueva Guzman, Maria, Froilan, Mary Carl, Fukuda, Christine, Barsegyan, Karina, Gough, Ellen, Lyman, Meghan, Makhija, Jinal, Marron, Stefania, Mikhail, Lydia, Noble-Wang, Judith, Pacilli, Massimo, Pedroza, Robert, Saavedra, Raheeb, Sexton, D Joseph, Shimabukuro, Julie, Thotapalli, Lahari, Zahn, Matthew, Huang, Susan S, Hayden, Mary K
• Format: Article
• Language: English
• Subjects: Major
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1093/cid/ciad752

Abstract Background Environmental contamination is suspected to play an important role in Candida auris transmission. Understanding speed and risks of contamination after room disinfection could inform environmental cleaning recommendations. Methods We conducted a prospective multicenter study of environmental contamination associated with C. auris colonization at 6 ventilator-capable skilled nursing facilities and 1 acute care hospital in Illinois and California. Known C. auris carriers were sampled at 5 body sites followed by sampling of nearby room surfaces before disinfection and at 0, 4, 8, and 12 hours after disinfection. Samples were cultured for C. auris and bacterial multidrug-resistant organisms (MDROs). Odds of surface contamination after disinfection were analyzed using multilevel generalized estimating equations. Results Among 41 known C. auris carriers, colonization was detected most frequently on palms/fingertips (76%) and nares (71%). C. auris contamination was detected on 32.2% (66/205) of room surfaces before disinfection and 20.5% (39/190) of room surfaces by 4 hours after disinfection. A higher number of C. auris–colonized body sites was associated with higher odds of environmental contamination at every time point following disinfection, adjusting for facility of residence. In the rooms of 38 (93%) C. auris carriers co-colonized with a bacterial MDRO, 2%–24% of surfaces were additionally contaminated with the same MDRO by 4 hours after disinfection. Conclusions C. auris can contaminate the healthcare environment rapidly after disinfection, highlighting the challenges associated with environmental disinfection. Future research should investigate long-acting disinfectants, antimicrobial surfaces, and more effective patient skin antisepsis to reduce the environmental reservoir of C. auris and bacterial MDROs in healthcare settings. Graphical Abstract Graphical Abstract This graphical abstract is also available at Tidbit: https://tidbitapp.io/tidbits/dr-a2ecef5d-9e09-4873-992f-e7655597be1c Skilled nursing facility and hospital participants had body sites cultured for Candida auris and multidrug-resistant bacteria along with environmental sampling at timed intervals after room disinfection. Contamination occurred rapidly after disinfection and was positively associated with number of colonized body sites.