Macrolide resistance of Mycoplasma pneumoniae in several regions of China from 2013 to 2019

• Published in: Epidemiology and infection 2024-04, Vol.152, p.e75-e75, Article e75
• Main Authors: Jiang, Yue, Dou, Haiwei, Xu, Bo, Xu, Baoping, Zhou, Wei, Wang, Hong, Ge, Lixia, Hu, Yinghui, Han, Xiaohua, Qin, Xuanguang, Li, Jing, Ye, Leping, Wu, Liqun, Zuo, Huimin, Zhang, Qi, Liu, Ling, Hu, Wenjuan, Shao, Junyan, Yin, Qiaomian, Han, Lina, Fu, Xiaoyan, Dong, Xiaopei, Dong, Yan, Fu, Yulin, Zhao, Mengmeng, Sun, Qing, Huo, Jingwei, Liu, Die, Liu, Wenkao, Li, Yunjuan, Wang, Yang, Xin, Deli, Shen, Kunling
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adults; Aged; Aged, 80 and over; Alveoli; Anti-Bacterial Agents - pharmacology; Antibiotics; Azithromycin; Child; Child, Preschool; China - epidemiology; Chinese medicine; Deoxyribonucleic acid; DNA; Drug resistance; Drug Resistance, Bacterial; Dyspnea; Erythromycin; Female; Fever; Hospitals; Humans; Infant; Infections; Lavage; Levofloxacin; Macrolides - pharmacology; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Mycoplasma pneumoniae; Mycoplasma pneumoniae - drug effects; Mycoplasma pneumoniae - genetics; Mycoplasma pneumoniae - isolation & purification; Original Paper; Pharynx; Pleural effusion; Pneumonia; Pneumonia, Mycoplasma - drug therapy; Pneumonia, Mycoplasma - epidemiology; Pneumonia, Mycoplasma - microbiology; Prevalence; Retrospective Studies; RNA, Ribosomal, 23S - genetics; rRNA; rRNA 23S; Software; Statistical analysis; Surveillance; Viral infections; Young Adult
• ISSN: 0950-2688; 1469-4409
• DOI: 10.1017/S0950268824000323

This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.