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Suppression of pancreatic cancer proliferation through TXNIP-mediated inhibition of the MAPK signaling pathway: TXNIP inhibits pancreatic cancer via the MAPK pathway
Thioredoxin-interacting protein (TXNIP) is a crucial thioredoxin-binding protein that is recognized as a tumor suppressor in diverse malignancies, such as breast cancer, lung cancer, hepatocellular carcinoma, and thyroid cancer. However, the specific role and molecular mechanisms of TXNIP in the pat...
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Published in: | Acta biochimica et biophysica Sinica 2024-01, Vol.56 (4), p.513-524 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Thioredoxin-interacting protein (TXNIP) is a crucial thioredoxin-binding protein that is
recognized as a tumor suppressor in diverse malignancies, such as breast cancer, lung
cancer, hepatocellular carcinoma, and thyroid cancer. However, the specific role and
molecular mechanisms of TXNIP in the pathogenesis and progression of pancreatic cancer
cells have not been determined. In this study, we investigate the relationship between
TXNIP expression and overall survival prognosis in pancreatic cancer patients. Mechanistic
studies are conducted to reveal the role of TXNIP in pancreatic cancer cell proliferation,
migration, and regulation during malignancy. Our findings indicate that patients with high
TXNIP expression have a more favorable prognosis.
In vitro
experiments
with pancreatic cell lines show that overexpression of TXNIP suppresses the proliferation
and migration of pancreatic cancer cells. Furthermore, we find that TXNIP inhibits the
activation of the MAPK signaling pathway, thereby decreasing the malignant potential of
pancreatic cancer. In conclusion, our study reveals TXNIP as a promising new predictive
marker and therapeutic target for pancreatic cancer. |
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ISSN: | 1672-9145 1745-7270 |
DOI: | 10.3724/abbs.2023286 |