Global research landscape and trends of cancer stem cells from 1997 to 2023: A bibliometric analysis

Cancer stem cells (CSCs) are a subset of cells with self-renewal ability and tumor generating potential. Accumulated evidence has revealed that CSCs were shown to contribute to tumorigenesis, metastasis, recurrence and resistance to chemoradiotherapy. Therefore, CSCs were regarded as promising thera...

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Bibliographic Details
Published in:Medicine (Baltimore) 2024-05, Vol.103 (20), p.e38125-e38125
Main Authors: Chen, Yuxian, Qu, Baozhen, Zheng, Keke, Liu, Yanhao, Lu, Linlin, Zhang, Xiaotao
Format: Article
Language:English
Subjects:
Bibliometrics
Biomedical Research - trends
Humans
Neoplasms - pathology
Neoplasms - therapy
Neoplastic Stem Cells
Observational Study
Tumor Microenvironment
Citations: Items that this one cites
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Summary:Cancer stem cells (CSCs) are a subset of cells with self-renewal ability and tumor generating potential. Accumulated evidence has revealed that CSCs were shown to contribute to tumorigenesis, metastasis, recurrence and resistance to chemoradiotherapy. Therefore, CSCs were regarded as promising therapeutic targets in cancer. This study is the first to reveal the development process, research hotspots, and trends of entire CSCs research field through bibliometric methods. All relevant publications on CSCs with more than 100 citations (notable papers) and the 100 most cited papers (top papers) during 1997 to 2023 were extracted and analyzed. Cancer research published the largest number of papers (184 papers). The USA accounted for the most publications (1326 papers). Rich, JN was the author with the most publications (56 papers) and the highest M-index (3.111). The most contributive institution was the University of Texas System (164 papers). Before 2007, research mainly focused on the definition and recognition of CSCs. Between 2007 and 2016, with the emergence of the terms such as "sonic hedgehog," "metabolism," "oxidative phosphorylation," and "epithelial mesenchymal transition," research began to shift toward exploring the mechanisms of CSCs. In 2016, the focus transitioned to the tumor microenvironment and the ecological niches. The analysis of papers published in major journals since 2021 showed that "transcription," "inhibition," and "chemoresistance" emerged as new focused issues. In general, the research focus has gradually shifted from basic biology to clinical transformation. "Tumor microenvironment" and "chemo-resistance" should be given more attention in the future.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000038125