Drug-related catatonia in youths: real-world insights from the WHO Safety Database

Catatonia is characterized by psychomotor alterations and reduced contact with the environment. Initially linked to schizophrenia, it also occurs in mood disorders or organic conditions. In children, catatonia remains poorly delineated, despite dramatically increasing the risk of premature death. As...

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Bibliographic Details
Published in:European child & adolescent psychiatry 2024-05, Vol.33 (5), p.1383-1393
Main Authors: Merino, Diane, Gérard, Alexandre O., Lavrut, Thibaud, Askenazy, Florence, Thümmler, Susanne, Montastruc, François, Drici, Milou-Daniel
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adverse Drug Reaction Reporting Systems
Ascription
Catatonia
Catatonia - chemically induced
Child
Child and Adolescent Psychiatry
Child, Preschool
Children
Chlorpromazine
Databases, Factual
Emotional disorders
Female
Haloperidol
Humans
Infant
Infants
Male
Medical conditions
Medicine
Medicine & Public Health
Mental disorders
Multiple drugs
Olanzapine
Original Contribution
Patients
Pediatrics
Premature mortality
Psychiatry
Psychotropic drugs
Safety
Schizophrenia
Vaccines
World Health Organization
Citations: Items that this one cites
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Summary:Catatonia is characterized by psychomotor alterations and reduced contact with the environment. Initially linked to schizophrenia, it also occurs in mood disorders or organic conditions. In children, catatonia remains poorly delineated, despite dramatically increasing the risk of premature death. As data on pediatric drug-induced catatonia bears many uncertainties, we aimed to characterize its age-dependent patterns, using real-world data from the WHO safety database (VigiBase®).VigiBase® was queried for all reports of catatonia registered up to December 8th 2022. Reports involving patients
ISSN:1018-8827
1435-165X
DOI:10.1007/s00787-023-02234-4