Role of angiomotin family members in human diseases (Review)

Angiomotin (Amot) family members, including Amot, Amot-like protein 1 (Amotl1) and Amot-like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesi...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2024-06, Vol.27 (6), Article 258
Main Authors: Wang, Haoyun, Ye, Meng, Jin, Xiaofeng
Format: Article
Language:English
Subjects:
Amino acids
Angiogenesis
Angiogenesis inhibitors
Blood vessels
Bone cancer
Care and treatment
Cell adhesion & migration
Cell growth
Cell migration
Diagnosis
Dosage and administration
Embryos
Gene expression
Health aspects
Kinases
Motility
Physiology
Proteins
Review
Risk factors
Roles
Signal transduction
Squamous cell carcinoma
Tumors
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Summary:Angiomotin (Amot) family members, including Amot, Amot-like protein 1 (Amotl1) and Amot-like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesis and tumorigenesis. Some studies have also demonstrated its regulation in signaling pathways such as the Hippo signaling pathway, AMPK signaling pathway and mTOR signaling pathways. Amot family members play an important role in neural stem cell differentiation, dendritic formation and synaptic maturation. In addition, an increasing number of studies have focused on their function in promoting and/or suppressing cancer, but the underlying mechanisms remain to be elucidated. The present review integrated relevant studies on upstream regulation and downstream signals of Amot family members, as well as the latest progress in physiological and pathological functions and clinical applications, hoping to offer important ideas for further research.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2024.12546