Strong ion gap and anion gap corrected for albumin and lactate in patients with sepsis in the intensive care unit

• Published in: International journal of physiology, pathophysiology and pharmacology pathophysiology and pharmacology, 2024, Vol.16 (2), p.10-27
• Main Authors: Alevrakis, Emmanouil, Papadakis, Dimitrios-Dorotheos, Vagionas, Dimitrios, Koutsoukou, Antonia, Pontikis, Konstantinos, Rovina, Nikoletta, Vasileiadis, Ioannis
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1944-8171; 1944-8171
• DOI: 10.62347/PTUU2265

Metabolic acidosis is very common amongst critically ill sepsis patients partly due to the presence of unmeasured ions in serum. These ions can be detected by anion gap (AG) or strong ion gap (SIG) concentration values. The purpose of this study is to assess the correlation and potential agreement of the two methods in critically ill patients with sepsis. The present is a retrospective study including septic patients admitted to the Intensive Care Unit from December 2014 to July 2016. The [SIG] and the [AG] corrected for albumin and lactate ([AG ]) were calculated on admission and on sepsis remission or deterioration. The correlation of the two parameters was assessed in all patient groups using the Pearson correlation coefficient and linear regression analysis and the agreement with Bland-Altman plots. ROC survival curves were also generated for the patients in relation to the values of [AG ], [SIG] and inorganic [SIG] ([SIG ]) on admission. There was a strong correlation linking [AG ] and [SIG] values (r>0.9, P