Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis

Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and anti...

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Bibliographic Details
Published in:Arthritis research 2002-01, Vol.4 (3), p.196-200, Article 196
Main Authors: Sakiniene, Egidija, Collins, L Vincent
Format: Article
Language:English
Subjects:
Animals
Antiarthritic agents
Arthritis, Experimental - drug therapy
Arthritis, Experimental - microbiology
Arthritis, Experimental - physiopathology
Arthritis, Infectious
Arthritis, Infectious - drug therapy
Arthritis, Infectious - microbiology
Arthritis, Infectious - physiopathology
Cloxacillin
Cloxacillin - therapeutic use
Cyclic N-Oxides
Disease Models, Animal
Drug therapy
Drug Therapy, Combination
Female
Free Radical Scavengers - therapeutic use
Infectious arthritis
Kidney - microbiology
Mice
Mice, Inbred Strains
Nitrogen Oxides - therapeutic use
Penicillins - therapeutic use
Severity of Illness Index
Staphylococcus aureus - immunology
Staphylococcus aureus infections
Synovitis - drug therapy
Synovitis - pathology
Testing
Treatment Outcome
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Summary:Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of Staphylococcus aureus arthritis.Three days after Naval Medical Research Institute (NMRI) mice were infected intravenously with S. aureus LS-1, daily treatment was started with cloxacillin alone, PBN alone, or cloxacillin and PBN. Arthritis, weight loss and general condition were evaluated for each mouse, and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental S. aureus arthritis, as evidenced by an increased cure rate. Thus, combinatorial antioxidant plus antibiotic anti-inflammatory therapies represent a potentially efficacious approach to the management of septic arthritis.
ISSN:1465-9905
1478-6362
1478-6354
1478-6362
1465-9913
DOI:10.1186/ar406