Single dose pharmacokinetics of terbinafine in cats

• Published in: Journal of feline medicine and surgery 2012-08, Vol.14 (8), p.540-544
• Main Authors: Wang, Ang, Ding, Huanzhong, Liu, Yiming, Gao, Yan, Zeng, Zhenling
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Antifungal Agents - administration & dosage; Antifungal Agents - pharmacokinetics; Area Under Curve; Cats - blood; Chromatography, High Pressure Liquid - veterinary; Cross-Over Studies; Drug Administration Schedule - veterinary; Half-Life; Naphthalenes - administration & dosage; Naphthalenes - pharmacokinetics; Original; Tablets; Terbinafine
• ISSN: 1098-612X; 1532-2750; 1532-2750
• DOI: 10.1177/1098612X12442280

The pharmacokinetics of terbinafine was studied in six healthy fasted cats following a single intravenous and oral administration at a dose of 10 mg/kg and 30 mg/kg, respectively, according to a two-period crossover design. Plasma terbinafine concentrations were determined using a reverse phase liquid chromatographic method. The pharmacokinetic parameters were calculated by non-compartmental analysis with WinNonlin 5.2.1 software. After intravenous administration, the terminal half-life and area under the curve from time 0 to infinity were 10.40 ± 4.56 h, 15.20 ± 3.61 h·µg/ml, respectively. After oral dosing, the mean maximum concentration was 3.22 ± 0.60 µg/ml, reached at 1.33 ± 0.41 h. The terminal half-life, area under the curve from time 0 to infinity and apparent volume of distribution were 8.01 ± 3.46 h, 13.77 ± 4.99 h·µg/ml, 25.63 ± 6.29 l/kg, respectively. The absolute bioavailability of terbinafine hydrochloride tablets after oral administration was 31.00 ± 10.85%. Although bioavailability was low, excellent penetration at the site of infection and low minimum inhibitory concentrations values provided terbinafine with good efficacy against dermatophyte infections.