Roles of vitamins in stem cells

Stem cells can differentiate to diverse cell types in our body, and they hold great promises in both basic research and clinical therapies. For specific stem cell types, distinctive nutritional and signaling components are required to maintain the proliferation capacity and differentiation potential...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2020-05, Vol.77 (9), p.1771-1791
Main Authors: Godoy-Parejo, Carlos, Deng, Chunhao, Zhang, Yumeng, Liu, Weiwei, Chen, Guokai
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Biology
Cell culture
Cell Differentiation
Cell Proliferation
Cell survival
Differentiation
Epigenesis, Genetic
Epigenetics
Humans
Life Sciences
Regenerative Medicine
Review
Signal Transduction
Stem cells
Stem Cells - cytology
Stem Cells - drug effects
Stem Cells - metabolism
Vitamins
Vitamins - pharmacology
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Summary:Stem cells can differentiate to diverse cell types in our body, and they hold great promises in both basic research and clinical therapies. For specific stem cell types, distinctive nutritional and signaling components are required to maintain the proliferation capacity and differentiation potential in cell culture. Various vitamins play essential roles in stem cell culture to modulate cell survival, proliferation and differentiation. Besides their common nutritional functions, specific vitamins are recently shown to modulate signal transduction and epigenetics. In this article, we will first review classical vitamin functions in both somatic and stem cell cultures. We will then focus on how stem cells could be modulated by vitamins beyond their nutritional roles. We believe that a better understanding of vitamin functions will significantly benefit stem cell research, and help realize their potentials in regenerative medicine.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-019-03352-6