Current perspective on the regulation of FOXO4 and its role in disease progression

Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOX...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2020-02, Vol.77 (4), p.651-663
Main Authors: Liu, Wen, Li, Yong, Luo, Bing
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Antitumor agents
Apoptosis
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cell cycle
Cell Cycle Proteins - analysis
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Proliferation
Deregulation
Disease Progression
Forkhead protein
Forkhead Transcription Factors - analysis
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
FOXO4 protein
Gene Expression Regulation, Neoplastic
Homeostasis
Humans
Life Sciences
miRNA
Neoplasms - genetics
Neoplasms - metabolism
Oxidative Stress
Post-translation
Protein Interaction Maps
Protein Processing, Post-Translational
Review
Senescence
Transcription
Transcriptional Activation
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Summary:Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases. In this review, we present recent findings on the regulation of FOXO4 in physiological and pathological conditions and provide an overview of the complex role of FOXO4 in disease development and response to therapy.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-019-03297-w