Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases

Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and...

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Published in:Cellular and molecular life sciences : CMLS 2020-09, Vol.77 (18), p.3525-3546
Main Authors: Wang, Dong, Tabti, Redouane, Elderwish, Sabria, Abou-Hamdan, Hussein, Djehal, Amel, Yu, Peng, Yurugi, Hajime, Rajalingam, Krishnaraj, Nebigil, Canan G., Désaubry, Laurent
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedical materials
Biomedicine
Cancer
Cell Biology
Coronary artery disease
Gene Expression
Heart diseases
Heart Diseases - metabolism
Heart Diseases - pathology
Heart Diseases - therapy
Humans
Life Sciences
Ligands
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Nervous System Diseases - metabolism
Nervous System Diseases - pathology
Nervous System Diseases - therapy
Neurodegenerative diseases
Neurological diseases
Osteoporosis
Osteoporosis - metabolism
Osteoporosis - pathology
Osteoporosis - therapy
Parkinson's disease
Prohibitin
Prohibitins
Protein Processing, Post-Translational
Proteins
Repressor Proteins - chemistry
Repressor Proteins - genetics
Repressor Proteins - metabolism
Review
Signal Transduction
Signaling
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Summary:Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-020-03475-1