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Molecular components and polarity of radial glial cells during cerebral cortex development
Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire...
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| Published in: | Cellular and molecular life sciences : CMLS 2018-03, Vol.75 (6), p.1027-1041 |
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| container_issue | 6 |
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| container_title | Cellular and molecular life sciences : CMLS |
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| creator | Chou, Fu-Sheng Li, Rong Wang, Pei-Shan |
| description | Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions. |
| doi_str_mv | 10.1007/s00018-017-2680-0 |
| format | article |
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The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-017-2680-0</identifier><identifier>PMID: 29018869</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Actin Cytoskeleton - metabolism ; Actin Cytoskeleton - ultrastructure ; Adherens Junctions - metabolism ; Adherens Junctions - ultrastructure ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Biology ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Polarity ; Cells ; Cerebral cortex ; Cerebral Cortex - cytology ; Cerebral Cortex - growth & development ; Cerebral Cortex - metabolism ; Cerebral Ventricles - cytology ; Cerebral Ventricles - growth & development ; Cerebral Ventricles - metabolism ; Ectoderm - cytology ; Ectoderm - growth & development ; Ectoderm - metabolism ; Embryo, Mammalian ; Epithelium ; Epithelium - growth & development ; Epithelium - metabolism ; Extracellular Matrix - metabolism ; Extracellular Matrix - ultrastructure ; Gene Expression Regulation, Developmental ; Glial cells ; Humans ; Life Sciences ; Molecular biology ; Molecular structure ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neuroglia - cytology ; Neuroglia - metabolism ; Neurons ; Pia Mater - cytology ; Pia Mater - growth & development ; Pia Mater - metabolism ; Polarity ; Radial glial cells ; Retinal ganglion cells ; Review</subject><ispartof>Cellular and molecular life sciences : CMLS, 2018-03, Vol.75 (6), p.1027-1041</ispartof><rights>Springer International Publishing AG 2017</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-afea8a1458151a5f4b7ca4f864610c153418887c090da9c16b4af53ddf7301323</citedby><cites>FETCH-LOGICAL-c494t-afea8a1458151a5f4b7ca4f864610c153418887c090da9c16b4af53ddf7301323</cites><orcidid>0000-0002-5770-0580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105283/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11105283/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29018869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chou, Fu-Sheng</creatorcontrib><creatorcontrib>Li, Rong</creatorcontrib><creatorcontrib>Wang, Pei-Shan</creatorcontrib><title>Molecular components and polarity of radial glial cells during cerebral cortex development</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.</description><subject>Actin Cytoskeleton - metabolism</subject><subject>Actin Cytoskeleton - ultrastructure</subject><subject>Adherens Junctions - metabolism</subject><subject>Adherens Junctions - ultrastructure</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Biology</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Polarity</subject><subject>Cells</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Ventricles - cytology</subject><subject>Cerebral Ventricles - growth & development</subject><subject>Cerebral Ventricles - metabolism</subject><subject>Ectoderm - cytology</subject><subject>Ectoderm - growth & development</subject><subject>Ectoderm - metabolism</subject><subject>Embryo, Mammalian</subject><subject>Epithelium</subject><subject>Epithelium - growth & development</subject><subject>Epithelium - metabolism</subject><subject>Extracellular Matrix - metabolism</subject><subject>Extracellular Matrix - ultrastructure</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Glial cells</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Molecular biology</subject><subject>Molecular structure</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neuroglia - cytology</subject><subject>Neuroglia - metabolism</subject><subject>Neurons</subject><subject>Pia Mater - cytology</subject><subject>Pia Mater - growth & development</subject><subject>Pia Mater - metabolism</subject><subject>Polarity</subject><subject>Radial glial cells</subject><subject>Retinal ganglion cells</subject><subject>Review</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kU1P3DAQhi1UBMvCD-CCIvXSS2DGsRP7VFWofEggLiAhLpbXcbZBSRzsZMX-exztQilSL_4Yv_PMjF9CjhFOEaA4CwCAIgUsUpoLSGGHzJBRSCUU-G17zgV93CcHITxHMRc03yP7VMY8kcsZebp1jTVjo31iXNu7znZDSHRXJr2LwXpYJ65KvC5r3STLZlqNbZqQlKOvu2W8eLvwU9T5wb4mpV3ZxvVtxByS3Uo3wR5t9zl5uPh9f36V3txdXp__ukkNk2xIdWW10Mi4QI6aV2xRGM0qkbMcwSDPWGxVFAYklFoazBdMVzwry6rIADOazcnPDbcfF60tTSwdG1K9r1vt18rpWv370tV_1NKtFCICpyKLhB9bgncvow2Dauswjak768agUPL4x5IyHqXfv0if3ei7OJ-iADSTkmYTEDcq410I3lYf3SCoyTq1sU5FrJqsUxBzTj6P8ZHx7lUU0I0g9NPXW_-39P-pb11epQQ</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Chou, Fu-Sheng</creator><creator>Li, Rong</creator><creator>Wang, Pei-Shan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5770-0580</orcidid></search><sort><creationdate>20180301</creationdate><title>Molecular components and polarity of radial glial cells during cerebral cortex development</title><author>Chou, Fu-Sheng ; Li, Rong ; Wang, Pei-Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-afea8a1458151a5f4b7ca4f864610c153418887c090da9c16b4af53ddf7301323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Actin Cytoskeleton - metabolism</topic><topic>Actin Cytoskeleton - ultrastructure</topic><topic>Adherens Junctions - metabolism</topic><topic>Adherens Junctions - ultrastructure</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Polarity</topic><topic>Cells</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Ventricles - cytology</topic><topic>Cerebral Ventricles - growth & development</topic><topic>Cerebral Ventricles - metabolism</topic><topic>Ectoderm - cytology</topic><topic>Ectoderm - growth & development</topic><topic>Ectoderm - metabolism</topic><topic>Embryo, Mammalian</topic><topic>Epithelium</topic><topic>Epithelium - growth & development</topic><topic>Epithelium - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Fu-Sheng</au><au>Li, Rong</au><au>Wang, Pei-Shan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular components and polarity of radial glial cells during cerebral cortex development</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>75</volume><issue>6</issue><spage>1027</spage><epage>1041</epage><pages>1027-1041</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29018869</pmid><doi>10.1007/s00018-017-2680-0</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-5770-0580</orcidid></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2018-03, Vol.75 (6), p.1027-1041 |
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| subjects | Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Adherens Junctions - metabolism Adherens Junctions - ultrastructure Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Polarity Cells Cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cerebral Ventricles - cytology Cerebral Ventricles - growth & development Cerebral Ventricles - metabolism Ectoderm - cytology Ectoderm - growth & development Ectoderm - metabolism Embryo, Mammalian Epithelium Epithelium - growth & development Epithelium - metabolism Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Gene Expression Regulation, Developmental Glial cells Humans Life Sciences Molecular biology Molecular structure Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroglia - cytology Neuroglia - metabolism Neurons Pia Mater - cytology Pia Mater - growth & development Pia Mater - metabolism Polarity Radial glial cells Retinal ganglion cells Review |
| title | Molecular components and polarity of radial glial cells during cerebral cortex development |
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