Accuracy of Bruch’s membrane opening minimum rim width and retinal nerve fiber layer thickness in glaucoma diagnosis depending on optic disc size

• Published in: Graefe's archive for clinical and experimental ophthalmology 2024-06, Vol.262 (6), p.1899-1910
• Main Authors: Englmaier, Verena Anna, Storp, Jens Julian, Leclaire, Martin Dominik, Lahme, Larissa, Brücher, Viktoria Constanze, Biermann, Julia, Diener, Raphael, Eter, Nicole
• Format: Article
• Language: English
• Subjects: Aged; Bruch Membrane - pathology; Classification; Eye; Female; Glaucoma; Glaucoma - diagnosis; Glaucoma - physiopathology; Glaucoma, Open-Angle - diagnosis; Glaucoma, Open-Angle - physiopathology; Humans; Intraocular Pressure - physiology; Male; Medicine; Medicine & Public Health; Middle Aged; Nerve Fibers - pathology; Ophthalmology; Optic Disk - pathology; Reproducibility of Results; Retina; Retinal Ganglion Cells - pathology; Retrospective Studies; ROC Curve; Tomography, Optical Coherence - methods; Visual Fields - physiology
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-024-06375-3

Background/aim The aim of this paper is to compare retinal nerve fiber layer thickness (RNFL) and Bruch’s membrane opening-based minimum rim width (BMO-MRW) in terms of their performance in detecting early and moderate/advanced glaucoma using receiver operating characteristics (ROC) analysis and the classification using the 5th percentile as a cut-off. Methods One hundred eyes from 100 patients with early glaucoma (mean deviation (MD):  -5.0 dB) were carefully matched to healthy controls based on optic disc size. Then, the dataset was divided, based on the 50th percentile of the measured Bruch’s membrane opening area (BMO-A), into small (BMO-A  1.95 mm 2 ). Finally, the discriminative performance of BMO-MRW and RNFL between glaucoma and controls using ROC analysis and the manufacturer’s classification based on the 5th percentile was analyzed. Results In discriminating between glaucoma and matched healthy controls, global BMO-MRW and global RNFL thickness had comparable areas under the ROC curve for eyes with early glaucoma and both small BMO-As (ROC ± confidence interval [CI] 0.91 [0.87 to 0.95] and 0.88 [0.83 to 0.93]) and large BMO-As (0.86 [0.82 to 0.92] and 0.84 [0.79 to 0.90]), as well as in moderate/advanced glaucoma with small BMO-As (0.99 [0.98 to 1.00] and 0.97 [0.95 to 1.00]) and large BMO-As (0.94 [0.91 to 0.98] and 0.97 [0.94 to 1.00]). Using the calculated 5th percentile as a threshold value, the sensitivities for the detection of early and moderate/advanced glaucoma were comparable for BMO-MRW and RNFL in eyes with small optic discs (early glaucoma: fifty-two percent and 61%; moderate/advanced glaucoma: ninety-one percent and 92%). In eyes with large optic discs, the sensitivity of BMO-MRW was inferior to that of RNFL for both early (38% versus 51%) and moderate/advanced (80% versus 91%) glaucoma. Conclusion Based on an ROC analysis, the discriminative performance of BMO-MRW and RNFL between patients with early and moderate/advanced glaucoma and a healthy control group matched based on optic disc size is comparable in eyes with BMO-As smaller and larger 1.95 mm 2 . Using a classification based on the 5th percentile, as used in clinical practice, RNFL is shown to be superior to BMO-MRW regarding sensitivity in glaucoma detection with large optic discs. This study underscores the importance of RNFL imaging and measurement