Racial and Ethnic Inequities in Cancer Care Continuity During the COVID-19 Pandemic Among Those With SARS-CoV-2

• Published in: JAMA network open 2024-05, Vol.7 (5), p.e2412050
• Main Authors: Islam, Jessica Y, Hathaway, Cassandra A, Hume, Emma, Turner, Kea, Hallanger-Johnson, Julie, Tworoger, Shelley S, Camacho-Rivera, Marlene
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cancer therapies; Continuity of Patient Care - statistics & numerical data; COVID-19; COVID-19 - epidemiology; COVID-19 - ethnology; COVID-19 - therapy; Cross-Sectional Studies; Cultural differences; Equity, Diversity, and Inclusion; Ethnic and Racial Minorities - statistics & numerical data; Ethnicity; Ethnicity - statistics & numerical data; Female; Healthcare Disparities - ethnology; Healthcare Disparities - statistics & numerical data; Hispanic or Latino - statistics & numerical data; Humans; Male; Middle Aged; Neoplasms - epidemiology; Neoplasms - ethnology; Neoplasms - therapy; Oncology; Online Only; Original Investigation; Pandemics; Race; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; United States - epidemiology
• ISSN: 2574-3805; 2574-3805
• DOI: 10.1001/jamanetworkopen.2024.12050

Racially and ethnically minoritized US adults were disproportionately impacted by the COVID-19 pandemic and experience poorer cancer outcomes, including inequities in cancer treatment delivery. To evaluate racial and ethnic disparities in cancer treatment delays and discontinuations (TDDs) among patients with cancer and SARS-CoV-2 during different waves of the COVID-19 pandemic in the United States. This cross-sectional study used data from the American Society of Clinical Oncology Survey on COVID-19 in Oncology Registry (data collected from April 2020 to September 2022), including patients with cancer also diagnosed with SARS-CoV-2 during their care at 69 US practices. Racial and ethnic differences were examined during 5 different waves of the COVID-19 pandemic in the United States based on case surge (before July 2020, July to November 2020, December 2020 to March 2021, April 2021 to February 2022, and March to September 2022). Race and ethnicity. TDD was defined as any cancer treatment postponed more than 2 weeks or cancelled with no plans to reschedule. To evaluate TDD associations with race and ethnicity, adjusted prevalence ratios (aPRs) were estimated using multivariable Poisson regression, accounting for nonindependence of patients within clinics, adjusting for age, sex, body mass index, comorbidities, cancer type, cancer extent, and SARS-CoV-2 severity (severe defined as death, hospitalization, intensive care unit admission, or mechanical ventilation). A total of 4054 patients with cancer and SARS-CoV-2 were included (143 [3.5%] American Indian or Alaska Native, 176 [4.3%] Asian, 517 [12.8%] Black or African American, 469 [11.6%] Hispanic or Latinx, and 2747 [67.8%] White; 2403 [59.3%] female; 1419 [35.1%] aged 50-64 years; 1928 [47.7%] aged ≥65 years). The analysis focused on patients scheduled (at SARS-CoV-2 diagnosis) to receive drug-based therapy (3682 [90.8%]), radiation therapy (382 [9.4%]), surgery (218 [5.4%]), or transplant (30 [0.7%]), of whom 1853 (45.7%) experienced TDD. Throughout the pandemic, differences in racial and ethnic inequities based on case surge with overall TDD decreased over time. In multivariable analyses, non-Hispanic Black (third wave: aPR, 1.56; 95% CI, 1.31-1.85) and Hispanic or Latinx (third wave: aPR, 1.35; 95% CI, 1.13-1.62) patients with cancer were more likely to experience TDD compared with non-Hispanic White patients during the first year of the pandemic. By 2022, non-Hispanic Asian patients (aPR, 1.51; 95% C