Temporal lobe epilepsy in a cat with a pyriform lobe oligodendroglioma and hippocampal necrosis

A 14-year-old male domestic shorthair cat presented with an acute onset of aggressive behaviour, fear and hypersalivation. Neurological examination revealed bilateral mydriasis and left-sided facial twitching and hemiparesis. Magnetic resonance imaging (MRI) showed moderate bilateral symmetrical T2-...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2012-12, Vol.14 (12), p.932-937
Main Authors: Vanhaesebrouck, An E, Posch, Barbara, Baker, Sam, Plessas, Ioannis N, Palmer, Anthony C, Constantino-Casas, Fernando
Format: Article
Language:English
Subjects:
aggression
Animals
Brain Neoplasms - complications
Brain Neoplasms - pathology
Brain Neoplasms - veterinary
Case Reports
case studies
Cat Diseases - pathology
Cat Diseases - surgery
Cats
epilepsy
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - veterinary
Fatal Outcome
fearfulness
hippocampus
histopathology
Magnetic Resonance Imaging - veterinary
magnetism
Male
males
medical treatment
medicine
necrosis
Necrosis - veterinary
neurological examination
neurons
Oligodendroglioma - complications
Oligodendroglioma - pathology
Oligodendroglioma - veterinary
sclerosis
surgery
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Summary:A 14-year-old male domestic shorthair cat presented with an acute onset of aggressive behaviour, fear and hypersalivation. Neurological examination revealed bilateral mydriasis and left-sided facial twitching and hemiparesis. Magnetic resonance imaging (MRI) showed moderate bilateral symmetrical T2-hyperintensity along the entire hippocampus and bilateral asymmetric T2-hyperintensity in the pyriform lobes. Marked bilateral contrast enhancement of the hippocampus was evident on post-contrast T1-weighted images. The partial complex seizures were refractory to medical treatment and the cat was euthanased 4 days after admission. The clinical and MRI findings were consistent with feline hippocampal necrosis (FHN). On histopathology, neuronal necrosis and astrocytosis were present in the hippocampi and pyriform lobes. In addition, an oligodendroglioma was detected in the right pyriform lobe. Contrary to previous reports of FHN in which no underlying cause could be identified, we believe that in this case the seizure focus arose from a neoplastic lesion within the right pyriform lobe. This unique case report represents the so-called ‘dual pathology’ of temporal lobe epilepsy in humans, in which an extrahippocampal lesion within the temporal lobe results in hippocampal sclerosis.
ISSN:1098-612X
1532-2750
1532-2750
DOI:10.1177/1098612X12454419