Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia

We report a 3-year-old male with findings of segmental agenesis of the corpus callosum, pituitary hypoplasia, and Chiari I malformation. The patient was born at 33 weeks and spent five weeks in the NICU for hypoglycemia, hypotension, and dyspnea. In infancy, the patient passed an adrenocorticotropic...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-04, Vol.16 (4), p.e58727
Main Authors: Haver, Jake, Junewick, Joseph J
Format: Article
Language:English
Subjects:
Age
Endocrinology/Diabetes/Metabolism
Growth hormones
Hearing loss
Hormone replacement therapy
Hypoglycemia
Hypotension
Insulin
Insulin-like growth factors
Magnetic resonance imaging
Neurology
Pituitary gland
Radiology
Sleep apnea
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c267t-cb62a6074a7278a2910fc332f03de5020bb4ae55a0d911e66023d66f56bd98333
container_end_page
container_issue 4
container_start_page e58727
container_title Curēus (Palo Alto, CA)
container_volume 16
creator Haver, Jake
Junewick, Joseph J
description We report a 3-year-old male with findings of segmental agenesis of the corpus callosum, pituitary hypoplasia, and Chiari I malformation. The patient was born at 33 weeks and spent five weeks in the NICU for hypoglycemia, hypotension, and dyspnea. In infancy, the patient passed an adrenocorticotropic hormone stimulation test, while cortisol, growth hormone, and insulin-like growth factor levels were within reference range. Following height and weight percentile regression the patient underwent arginine and clonidine stimulation testing at 3 years of age, prompting pituitary evaluation via MRI. The results provided exemplary neuroimaging of segmental callosal agenesis, in which the genu and splenium form despite the absence of the callosal body. This finding adds support to a newer theory of embryological callosal development where progression does not occur linearly in the rosto-caudal direction.
doi_str_mv 10.7759/cureus.58727
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11110639</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3062845923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-cb62a6074a7278a2910fc332f03de5020bb4ae55a0d911e66023d66f56bd98333</originalsourceid><addsrcrecordid>eNpVkFFLwzAUhYMoTubefJaAr3beJG3SPsko6oSBgoqPIW3TLaNtatIK-_d2bo55X-6Fezjn4yB0RWAqRJTc5b3TvZ9GsaDiBF1QwuMgJnF4enSP0MT7NQAQEBQEnKMRi4VIqGAXKH3Ty1o3narwbKkb7Y3HtsTdSuPUurb3OFVVZX1f40_TrfCr6XrTKbfB801r20p5oy7RWakqryf7PUYfjw_v6TxYvDw9p7NFkFMuuiDPOFUcRKgG2FjRhECZM0ZLYIWOgEKWhUpHkYIiIURzDpQVnJcRz4okZoyN0f3Ot-2zWhf5gO1UJVtn6gFIWmXk_09jVnJpvyUZBjhLBoebvYOzX732nVzb3jUDtGTAaRxGCd3m3O5UubPeO10eIgjIbe1yV7v8rX2QXx9jHcR_JbMfkgJ--g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3062845923</pqid></control><display><type>article</type><title>Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Haver, Jake ; Junewick, Joseph J</creator><creatorcontrib>Haver, Jake ; Junewick, Joseph J</creatorcontrib><description>We report a 3-year-old male with findings of segmental agenesis of the corpus callosum, pituitary hypoplasia, and Chiari I malformation. The patient was born at 33 weeks and spent five weeks in the NICU for hypoglycemia, hypotension, and dyspnea. In infancy, the patient passed an adrenocorticotropic hormone stimulation test, while cortisol, growth hormone, and insulin-like growth factor levels were within reference range. Following height and weight percentile regression the patient underwent arginine and clonidine stimulation testing at 3 years of age, prompting pituitary evaluation via MRI. The results provided exemplary neuroimaging of segmental callosal agenesis, in which the genu and splenium form despite the absence of the callosal body. This finding adds support to a newer theory of embryological callosal development where progression does not occur linearly in the rosto-caudal direction.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.58727</identifier><identifier>PMID: 38779273</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age ; Endocrinology/Diabetes/Metabolism ; Growth hormones ; Hearing loss ; Hormone replacement therapy ; Hypoglycemia ; Hypotension ; Insulin ; Insulin-like growth factors ; Magnetic resonance imaging ; Neurology ; Pituitary gland ; Radiology ; Sleep apnea</subject><ispartof>Curēus (Palo Alto, CA), 2024-04, Vol.16 (4), p.e58727</ispartof><rights>Copyright © 2024, Haver et al.</rights><rights>Copyright © 2024, Haver et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Haver et al. 2024 Haver et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-cb62a6074a7278a2910fc332f03de5020bb4ae55a0d911e66023d66f56bd98333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3062845923/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3062845923?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,25740,27911,27912,36999,44577,53778,53780,74881</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38779273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haver, Jake</creatorcontrib><creatorcontrib>Junewick, Joseph J</creatorcontrib><title>Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>We report a 3-year-old male with findings of segmental agenesis of the corpus callosum, pituitary hypoplasia, and Chiari I malformation. The patient was born at 33 weeks and spent five weeks in the NICU for hypoglycemia, hypotension, and dyspnea. In infancy, the patient passed an adrenocorticotropic hormone stimulation test, while cortisol, growth hormone, and insulin-like growth factor levels were within reference range. Following height and weight percentile regression the patient underwent arginine and clonidine stimulation testing at 3 years of age, prompting pituitary evaluation via MRI. The results provided exemplary neuroimaging of segmental callosal agenesis, in which the genu and splenium form despite the absence of the callosal body. This finding adds support to a newer theory of embryological callosal development where progression does not occur linearly in the rosto-caudal direction.</description><subject>Age</subject><subject>Endocrinology/Diabetes/Metabolism</subject><subject>Growth hormones</subject><subject>Hearing loss</subject><subject>Hormone replacement therapy</subject><subject>Hypoglycemia</subject><subject>Hypotension</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>Magnetic resonance imaging</subject><subject>Neurology</subject><subject>Pituitary gland</subject><subject>Radiology</subject><subject>Sleep apnea</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkFFLwzAUhYMoTubefJaAr3beJG3SPsko6oSBgoqPIW3TLaNtatIK-_d2bo55X-6Fezjn4yB0RWAqRJTc5b3TvZ9GsaDiBF1QwuMgJnF4enSP0MT7NQAQEBQEnKMRi4VIqGAXKH3Ty1o3narwbKkb7Y3HtsTdSuPUurb3OFVVZX1f40_TrfCr6XrTKbfB801r20p5oy7RWakqryf7PUYfjw_v6TxYvDw9p7NFkFMuuiDPOFUcRKgG2FjRhECZM0ZLYIWOgEKWhUpHkYIiIURzDpQVnJcRz4okZoyN0f3Ot-2zWhf5gO1UJVtn6gFIWmXk_09jVnJpvyUZBjhLBoebvYOzX732nVzb3jUDtGTAaRxGCd3m3O5UubPeO10eIgjIbe1yV7v8rX2QXx9jHcR_JbMfkgJ--g</recordid><startdate>20240422</startdate><enddate>20240422</enddate><creator>Haver, Jake</creator><creator>Junewick, Joseph J</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20240422</creationdate><title>Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia</title><author>Haver, Jake ; Junewick, Joseph J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-cb62a6074a7278a2910fc332f03de5020bb4ae55a0d911e66023d66f56bd98333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Endocrinology/Diabetes/Metabolism</topic><topic>Growth hormones</topic><topic>Hearing loss</topic><topic>Hormone replacement therapy</topic><topic>Hypoglycemia</topic><topic>Hypotension</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>Magnetic resonance imaging</topic><topic>Neurology</topic><topic>Pituitary gland</topic><topic>Radiology</topic><topic>Sleep apnea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haver, Jake</creatorcontrib><creatorcontrib>Junewick, Joseph J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haver, Jake</au><au>Junewick, Joseph J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-04-22</date><risdate>2024</risdate><volume>16</volume><issue>4</issue><spage>e58727</spage><pages>e58727-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>We report a 3-year-old male with findings of segmental agenesis of the corpus callosum, pituitary hypoplasia, and Chiari I malformation. The patient was born at 33 weeks and spent five weeks in the NICU for hypoglycemia, hypotension, and dyspnea. In infancy, the patient passed an adrenocorticotropic hormone stimulation test, while cortisol, growth hormone, and insulin-like growth factor levels were within reference range. Following height and weight percentile regression the patient underwent arginine and clonidine stimulation testing at 3 years of age, prompting pituitary evaluation via MRI. The results provided exemplary neuroimaging of segmental callosal agenesis, in which the genu and splenium form despite the absence of the callosal body. This finding adds support to a newer theory of embryological callosal development where progression does not occur linearly in the rosto-caudal direction.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38779273</pmid><doi>10.7759/cureus.58727</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2168-8184
ispartof Curēus (Palo Alto, CA), 2024-04, Vol.16 (4), p.e58727
issn 2168-8184
2168-8184
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11110639
source Publicly Available Content Database; PubMed Central
subjects Age
Endocrinology/Diabetes/Metabolism
Growth hormones
Hearing loss
Hormone replacement therapy
Hypoglycemia
Hypotension
Insulin
Insulin-like growth factors
Magnetic resonance imaging
Neurology
Pituitary gland
Radiology
Sleep apnea
title Segmental Agenesis of the Corpus Callosum With Pituitary Hypoplasia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T14%3A08%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Segmental%20Agenesis%20of%20the%20Corpus%20Callosum%20With%20Pituitary%20Hypoplasia&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Haver,%20Jake&rft.date=2024-04-22&rft.volume=16&rft.issue=4&rft.spage=e58727&rft.pages=e58727-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.58727&rft_dat=%3Cproquest_pubme%3E3062845923%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c267t-cb62a6074a7278a2910fc332f03de5020bb4ae55a0d911e66023d66f56bd98333%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3062845923&rft_id=info:pmid/38779273&rfr_iscdi=true