Recent advances in the development of new transgenic animal technology

Transgenic animal technology is one of the fastest growing biotechnology areas. It is used to integrate exogenous genes into the animal genome by genetic engineering technology so that these genes can be inherited and expressed by offspring. The transgenic efficiency and precise control of gene expr...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2013-03, Vol.70 (5), p.815-828
Main Author: Miao, Xiangyang
Format: Article
Language:English
Subjects:
Animal breeding
Animal diseases
Animals
Animals, Genetically Modified - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioreactors
Biotechnology
Cell Biology
Gene Targeting - methods
Genes
Genetic engineering
Genetic Engineering - methods
Genetic improvement
Humans
Life Sciences
Livestock
Livestock production
Offspring
Review
RNA Interference
Stem cells
Technology
Transgenic animals
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Summary:Transgenic animal technology is one of the fastest growing biotechnology areas. It is used to integrate exogenous genes into the animal genome by genetic engineering technology so that these genes can be inherited and expressed by offspring. The transgenic efficiency and precise control of gene expression are the key limiting factors in the production of transgenic animals. A variety of transgenic technologies are available. Each has its own advantages and disadvantages and needs further study because of unresolved technical and safety issues. Further studies will allow transgenic technology to explore gene function, animal genetic improvement, bioreactors, animal disease models, and organ transplantation. This article reviews the recently developed animal transgenic technologies, including the germ line stem cell-mediated method to improve efficiency, gene targeting to improve accuracy, RNA interference-mediated gene silencing technology, zinc-finger nuclease gene targeting technology and induced pluripotent stem cell technology. These new transgenic techniques can provide a better platform to develop transgenic animals for breeding new animal varieties and promote the development of medical sciences, livestock production, and other fields.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-012-1081-7