Human dendritic cell subsets and function in health and disease

The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated immunity or induce tolerance to specific antigens. The innate functions of dendritic cells themselves may also be...

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Bibliographic Details
Published in:Cellular and Molecular Life Sciences 2015-11, Vol.72 (22), p.4309-4325
Main Authors: O’Keeffe, Meredith, Mok, Wai Hong, Radford, Kristen J.
Format: Article
Language:English
Subjects:
Antigen presentation
Antigen Presentation - immunology
Antigens, CD1 - immunology
Antigens, CD1 - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular biology
Cytokines
Cytokines - immunology
Cytokines - metabolism
Dendritic Cells - immunology
Dendritic Cells - metabolism
Glycoproteins - immunology
Glycoproteins - metabolism
Humans
Immune System Diseases - immunology
Immunity, Cellular - immunology
Infections - immunology
Life Sciences
Lymphocyte Activation - immunology
Review
T-Lymphocytes - immunology
Vaccines
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Summary:The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated immunity or induce tolerance to specific antigens. The innate functions of dendritic cells themselves may also be targeted by inhibitors or activators that would target a specific function such as interferon production, potentially important in autoimmune disease and chronic viral infections. Importantly targeting dendritic cells requires detailed knowledge of both the surface phenotype and function of each dendritic cell subset, including how they may respond to different types of vaccine adjuvants, their ability to produce soluble mediators and to process and present antigens and induce priming of naïve T cells. This review summarizes our knowledge of the functional attributes of the human dendritic cell subsets in the steady state and upon activation and their roles in human disease.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-015-2005-0