Structure and function of interleukin-22 and other members of the interleukin-10 family

The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-λs (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor compl...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2010-09, Vol.67 (17), p.2909-2935
Main Authors: Trivella, Daniela Barretto Barbosa, Ferreira-Júnior, José Ribamar, Dumoutier, Laure, Renauld, Jean-Christophe, Polikarpov, Igor
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Binding sites
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cytokines
Humans
Interleukin-10 - chemistry
Interleukin-10 - classification
Interleukin-10 - metabolism
Interleukin-10 family
Interleukin-22
Interleukins - chemistry
Interleukins - metabolism
Life Sciences
Membrane receptors
Models, Molecular
Molecular biology
Molecular Sequence Data
Molecular structure
Phylogeny
Protein Multimerization
Proteins
Receptors, Cytokine - metabolism
Review
Sequence Alignment
Signal Transduction - physiology
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Summary:The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-λs (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-010-0380-0