Bile Duct Mixed Neuroendocrine-nonendocrine Neoplasm with a Complete Response to Chemoradiotherapy

The incidence of neuroendocrine carcinomas arising from the bile duct is low, and that of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) is even lower; therefore, there is no standard treatment for MiNENs. Choosing the appropriate treatment in clinical practice is difficult. We herein re...

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Bibliographic Details
Published in:Internal Medicine 2024/05/01, Vol.63(9), pp.1243-1246
Main Authors: Horita, Yosuke, Mihara, Yoshiaki, Mizuide, Masafumi, Noda, Shin-ei, Kawasaki, Tomonori, Yasuda, Masanori, Kato, Shingo, Ryozawa, Shomei, Hamaguchi, Tetsuya
Format: Article
Language:English
Subjects:
Aged
bile duct cancer
Bile Duct Neoplasms - diagnostic imaging
Bile Duct Neoplasms - drug therapy
Bile Duct Neoplasms - therapy
Bile ducts
Carcinoma, Neuroendocrine - diagnostic imaging
Carcinoma, Neuroendocrine - drug therapy
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - therapy
Case Report
Case reports
Chemoradiotherapy
Chemoradiotherapy - methods
Humans
Male
mixed neuroendocrine-nonendocrine neoplasm (MiNEN)
neuroendocrine cancer
Neuroendocrine tumors
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - therapy
Treatment Outcome
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Summary:The incidence of neuroendocrine carcinomas arising from the bile duct is low, and that of mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) is even lower; therefore, there is no standard treatment for MiNENs. Choosing the appropriate treatment in clinical practice is difficult. We herein report a case of unresectable extrahepatic bile duct MiNEN in a 66-year-old man who received curative chemoradiotherapy and achieved a complete response, remaining recurrence-free for 2.5 years. We consider the findings of this case to be valuable in selecting a treatment strategy for unresectable bile duct MiNENs.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2555-23