Skin microbiome attributes associate with biophysical skin ageing

Two major arms of skin ageing are changes in the skin's biophysical conditions and alterations in the skin microbiome. This work partitioned both arms to study their interaction in detail. Leveraging the resolution provided by shotgun metagenomics, we explored how skin microbial species, strain...

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Bibliographic Details
Published in:Experimental dermatology 2023-09, Vol.32 (9), p.1546-1556
Main Authors: Zhou, Wei, Fleming, Elizabeth, Legendre, Guylaine, Roux, Lauriane, Latreille, Julie, Gendronneau, Gaëlle, Forestier, Sandra, Oh, Julia
Format: Article
Language:English
Subjects:
Aging
Anti-Bacterial Agents
Antibiotic resistance
Bacteria
Diffusion coefficient
Metagenomics
Microbiomes
Microbiota - genetics
Nosocomial infection
Skin - microbiology
Skin Aging
Skin tests
Strains (organisms)
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Summary:Two major arms of skin ageing are changes in the skin's biophysical conditions and alterations in the skin microbiome. This work partitioned both arms to study their interaction in detail. Leveraging the resolution provided by shotgun metagenomics, we explored how skin microbial species, strains and gene content interact with the biophysical traits of the skin during ageing. With a dataset well-controlled for confounding factors, we found that skin biophysical traits, especially the collagen diffusion coefficient, are associated with the composition and the functional potential of the skin microbiome, including the abundance of bacterial strains found in nosocomial infections and the abundance of antibiotic resistance genes. Our findings reveal important associations between skin biophysical features and ageing-related changes in the skin microbiome and generate testable hypotheses for the mechanisms of such associations.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.14863