NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy...

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Published in:ACS applied materials & interfaces 2024-05, Vol.16 (20), p.25622-25636
Main Authors: Thirumurugan, Senthilkumar, Muthiah, Kayalvizhi Samuvel, Lin, Yu-Chien, Dhawan, Udesh, Liu, Wai-Ching, Wang, An-Ni, Liu, Xinke, Hsiao, Michael, Tseng, Ching-Li, Chung, Ren-Jei
Format: Article
Language:English
Subjects:
Animals
Biological and Medical Applications of Materials and Interfaces
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cell Line, Tumor
Female
Humans
Hyperthermia, Induced
Infrared Rays
Iron - chemistry
Methotrexate - chemistry
Methotrexate - pharmacology
Mice
Mice, Inbred BALB C
Mice, Nude
Nanotubes - chemistry
Photothermal Therapy
Selenium Compounds - chemistry
Selenium Compounds - pharmacology
Selenium Compounds - radiation effects
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Summary:Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.3c18450