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Activation of CD47 receptors causes histamine secretion from mast cells
Mast cells play pivotal roles in allergic and inflammatory processes via distinct activation pathways. Mucosal and serosal mast cells are activated by the IgE/FcεRI pathway, while only serosal mast cells are activated by basic secretagogues. We show that CD47 receptors are expressed on rat peritonea...
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Published in: | Cellular and molecular life sciences : CMLS 2009-04, Vol.66 (7), p.1271-1282 |
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creator | Sick, E Niederhoffer, N Takeda, K Landry, Y Gies, J.-P |
description | Mast cells play pivotal roles in allergic and inflammatory processes via distinct activation pathways. Mucosal and serosal mast cells are activated by the IgE/FcεRI pathway, while only serosal mast cells are activated by basic secretagogues. We show that CD47 receptors are expressed on rat peritoneal mast cells. 4N1K, a peptide agonist of CD47, rapidly caused exocytosis. Such exocytosis required increased intracellular calcium and was inhibited by pertussis toxin and an antibody against the βγ dimer of a Gi protein. Cooperation with integrins and glycosylphosphatidylinositol-anchored proteins was necessary, since anti-integrin antibodies and pretreatment with phosphatidylinositol-phospholipase C reduced exocytosis. Depletion of membrane cholesterol inhibited exocytosis and decreased CD47 in lipid rafts, consistent with a CD47/integrin/Gi protein complex being located in rafts. An anti-CD47 antibody inhibited exocytosis induced by 4N1K and by mastoparan and spermine, suggesting that basic secretagogues might target CD47. We propose that 4N1K-stimulated mast cell exocytosis involves a CD47/integrin/Gi protein complex. |
doi_str_mv | 10.1007/s00018-009-8778-2 |
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Mucosal and serosal mast cells are activated by the IgE/FcεRI pathway, while only serosal mast cells are activated by basic secretagogues. We show that CD47 receptors are expressed on rat peritoneal mast cells. 4N1K, a peptide agonist of CD47, rapidly caused exocytosis. Such exocytosis required increased intracellular calcium and was inhibited by pertussis toxin and an antibody against the βγ dimer of a Gi protein. Cooperation with integrins and glycosylphosphatidylinositol-anchored proteins was necessary, since anti-integrin antibodies and pretreatment with phosphatidylinositol-phospholipase C reduced exocytosis. Depletion of membrane cholesterol inhibited exocytosis and decreased CD47 in lipid rafts, consistent with a CD47/integrin/Gi protein complex being located in rafts. An anti-CD47 antibody inhibited exocytosis induced by 4N1K and by mastoparan and spermine, suggesting that basic secretagogues might target CD47. We propose that 4N1K-stimulated mast cell exocytosis involves a CD47/integrin/Gi protein complex.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-009-8778-2</identifier><identifier>PMID: 19205621</identifier><language>eng</language><publisher>Basel: Basel : Birkhäuser-Verlag</publisher><subject>Animals ; Antibodies, Monoclonal - pharmacology ; Biochemistry ; Biochemistry, Molecular Biology ; Biomedical and Life Sciences ; Biomedicine ; CD47 Antigen - immunology ; CD47 Antigen - physiology ; Cell Biology ; Cell Membrane - physiology ; Cells ; Cellular Biology ; Cholesterol - physiology ; Exocytosis ; Glycosylphosphatidylinositols - metabolism ; GTP-Binding Protein beta Subunits - immunology ; GTP-Binding Protein beta Subunits - metabolism ; GTP-Binding Protein gamma Subunits - immunology ; GTP-Binding Protein gamma Subunits - metabolism ; Histamine - biosynthesis ; Histamine Release - physiology ; In Vitro Techniques ; Integrin beta Chains - immunology ; Intercellular Signaling Peptides and Proteins ; Life Sciences ; Male ; Mast Cells - drug effects ; Mast Cells - metabolism ; Membrane Microdomains - physiology ; Oligopeptides - pharmacology ; Peptides ; Peptides - pharmacology ; Pertussis Toxin - pharmacology ; Protein Multimerization ; Proteins ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Research Article ; Rodents ; Spermine - pharmacology ; Studies ; Toxins ; Type C Phospholipases - metabolism ; Wasp Venoms - pharmacology</subject><ispartof>Cellular and molecular life sciences : CMLS, 2009-04, Vol.66 (7), p.1271-1282</ispartof><rights>Birkhäuser Verlag, Basel 2009</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-c12f60de139af52347d6bdaec98a4073c9a3307b0a5f1efc97f573b54132f3903</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131455/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131455/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19205621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00406408$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sick, E</creatorcontrib><creatorcontrib>Niederhoffer, N</creatorcontrib><creatorcontrib>Takeda, K</creatorcontrib><creatorcontrib>Landry, Y</creatorcontrib><creatorcontrib>Gies, J.-P</creatorcontrib><title>Activation of CD47 receptors causes histamine secretion from mast cells</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Mast cells play pivotal roles in allergic and inflammatory processes via distinct activation pathways. Mucosal and serosal mast cells are activated by the IgE/FcεRI pathway, while only serosal mast cells are activated by basic secretagogues. We show that CD47 receptors are expressed on rat peritoneal mast cells. 4N1K, a peptide agonist of CD47, rapidly caused exocytosis. Such exocytosis required increased intracellular calcium and was inhibited by pertussis toxin and an antibody against the βγ dimer of a Gi protein. Cooperation with integrins and glycosylphosphatidylinositol-anchored proteins was necessary, since anti-integrin antibodies and pretreatment with phosphatidylinositol-phospholipase C reduced exocytosis. Depletion of membrane cholesterol inhibited exocytosis and decreased CD47 in lipid rafts, consistent with a CD47/integrin/Gi protein complex being located in rafts. An anti-CD47 antibody inhibited exocytosis induced by 4N1K and by mastoparan and spermine, suggesting that basic secretagogues might target CD47. We propose that 4N1K-stimulated mast cell exocytosis involves a CD47/integrin/Gi protein complex.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Biochemistry</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD47 Antigen - immunology</subject><subject>CD47 Antigen - physiology</subject><subject>Cell Biology</subject><subject>Cell Membrane - physiology</subject><subject>Cells</subject><subject>Cellular Biology</subject><subject>Cholesterol - physiology</subject><subject>Exocytosis</subject><subject>Glycosylphosphatidylinositols - metabolism</subject><subject>GTP-Binding Protein beta Subunits - immunology</subject><subject>GTP-Binding Protein beta Subunits - metabolism</subject><subject>GTP-Binding Protein gamma Subunits - immunology</subject><subject>GTP-Binding Protein gamma Subunits - metabolism</subject><subject>Histamine - biosynthesis</subject><subject>Histamine Release - physiology</subject><subject>In Vitro Techniques</subject><subject>Integrin beta Chains - immunology</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Membrane Microdomains - physiology</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptides</subject><subject>Peptides - pharmacology</subject><subject>Pertussis Toxin - pharmacology</subject><subject>Protein Multimerization</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Research Article</subject><subject>Rodents</subject><subject>Spermine - pharmacology</subject><subject>Studies</subject><subject>Toxins</subject><subject>Type C Phospholipases - metabolism</subject><subject>Wasp Venoms - pharmacology</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vEzEQhi0EoqXwA7jAigOIw8KMP9b2CUUBWqRIHKASN8tx7GSr7DrYu5H493jZiEIP9cWW55l3Pl5CniO8QwD5PgMAqhpA10pKVdMH5Bw5hVqDxIend6PojzPyJOebAgtFm8fkDDUF0VA8J5cLN7RHO7Sxr2Kolh-5rJJ3_jDElCtnx-xztWvzYLu291X2Lvk_cEixqzqbh8r5_T4_JY-C3Wf_7HRfkOvPn74vr-rV18svy8WqdkLhUDukoYGNR6ZtEJRxuWnWG-udVpaDZE5bxkCuwYqAPjgtg5BsLTgyGpgGdkE-zLqHcd35jfP9kOzeHFLb2fTLRNua_yN9uzPbeDSIyJALURTezgq7O3lXi5WZ_gA4NBzUEQv75lQtxZ-jz4Pp2jzNa3sfx2yk4KocrQr5-l6ykSClBl7AV3fAmzimvuzMUGQCUYtJDWfIpZhz8uFvowhmst7M1pdetZmsN7TkvPh3M7cZJ68LQGcgl1C_9em28n2qL-ekYKOx29Rmc_2NAjLABvk0-W_Y2cEk</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Sick, E</creator><creator>Niederhoffer, N</creator><creator>Takeda, K</creator><creator>Landry, Y</creator><creator>Gies, J.-P</creator><general>Basel : Birkhäuser-Verlag</general><general>Birkhäuser-Verlag</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Activation of CD47 receptors causes histamine secretion from mast cells</title><author>Sick, E ; Niederhoffer, N ; Takeda, K ; Landry, Y ; Gies, J.-P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-c12f60de139af52347d6bdaec98a4073c9a3307b0a5f1efc97f573b54132f3903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Biochemistry</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD47 Antigen - immunology</topic><topic>CD47 Antigen - physiology</topic><topic>Cell Biology</topic><topic>Cell Membrane - physiology</topic><topic>Cells</topic><topic>Cellular Biology</topic><topic>Cholesterol - physiology</topic><topic>Exocytosis</topic><topic>Glycosylphosphatidylinositols - metabolism</topic><topic>GTP-Binding Protein beta Subunits - immunology</topic><topic>GTP-Binding Protein beta Subunits - metabolism</topic><topic>GTP-Binding Protein gamma Subunits - immunology</topic><topic>GTP-Binding Protein gamma Subunits - metabolism</topic><topic>Histamine - biosynthesis</topic><topic>Histamine Release - physiology</topic><topic>In Vitro Techniques</topic><topic>Integrin beta Chains - immunology</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Membrane Microdomains - physiology</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptides</topic><topic>Peptides - pharmacology</topic><topic>Pertussis Toxin - pharmacology</topic><topic>Protein Multimerization</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Research Article</topic><topic>Rodents</topic><topic>Spermine - pharmacology</topic><topic>Studies</topic><topic>Toxins</topic><topic>Type C Phospholipases - metabolism</topic><topic>Wasp Venoms - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sick, E</creatorcontrib><creatorcontrib>Niederhoffer, N</creatorcontrib><creatorcontrib>Takeda, K</creatorcontrib><creatorcontrib>Landry, Y</creatorcontrib><creatorcontrib>Gies, J.-P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sick, E</au><au>Niederhoffer, N</au><au>Takeda, K</au><au>Landry, Y</au><au>Gies, J.-P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of CD47 receptors causes histamine secretion from mast cells</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>66</volume><issue>7</issue><spage>1271</spage><epage>1282</epage><pages>1271-1282</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Mast cells play pivotal roles in allergic and inflammatory processes via distinct activation pathways. Mucosal and serosal mast cells are activated by the IgE/FcεRI pathway, while only serosal mast cells are activated by basic secretagogues. We show that CD47 receptors are expressed on rat peritoneal mast cells. 4N1K, a peptide agonist of CD47, rapidly caused exocytosis. Such exocytosis required increased intracellular calcium and was inhibited by pertussis toxin and an antibody against the βγ dimer of a Gi protein. Cooperation with integrins and glycosylphosphatidylinositol-anchored proteins was necessary, since anti-integrin antibodies and pretreatment with phosphatidylinositol-phospholipase C reduced exocytosis. Depletion of membrane cholesterol inhibited exocytosis and decreased CD47 in lipid rafts, consistent with a CD47/integrin/Gi protein complex being located in rafts. An anti-CD47 antibody inhibited exocytosis induced by 4N1K and by mastoparan and spermine, suggesting that basic secretagogues might target CD47. We propose that 4N1K-stimulated mast cell exocytosis involves a CD47/integrin/Gi protein complex.</abstract><cop>Basel</cop><pub>Basel : Birkhäuser-Verlag</pub><pmid>19205621</pmid><doi>10.1007/s00018-009-8778-2</doi><tpages>12</tpages></addata></record> |
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subjects | Animals Antibodies, Monoclonal - pharmacology Biochemistry Biochemistry, Molecular Biology Biomedical and Life Sciences Biomedicine CD47 Antigen - immunology CD47 Antigen - physiology Cell Biology Cell Membrane - physiology Cells Cellular Biology Cholesterol - physiology Exocytosis Glycosylphosphatidylinositols - metabolism GTP-Binding Protein beta Subunits - immunology GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - immunology GTP-Binding Protein gamma Subunits - metabolism Histamine - biosynthesis Histamine Release - physiology In Vitro Techniques Integrin beta Chains - immunology Intercellular Signaling Peptides and Proteins Life Sciences Male Mast Cells - drug effects Mast Cells - metabolism Membrane Microdomains - physiology Oligopeptides - pharmacology Peptides Peptides - pharmacology Pertussis Toxin - pharmacology Protein Multimerization Proteins Rats Rats, Wistar Reactive Oxygen Species - metabolism Research Article Rodents Spermine - pharmacology Studies Toxins Type C Phospholipases - metabolism Wasp Venoms - pharmacology |
title | Activation of CD47 receptors causes histamine secretion from mast cells |
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