Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis

The chemical screening of an octocoral identifed as has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin...

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Bibliographic Details
Published in:RSC advances 2024-05, Vol.14 (24), p.17195-17201
Main Authors: Do, Hai Nhat, Chen, Yu-Ta, Chien, Su-Ying, Chen, You-Ying, Zhang, Mingzi M, Tsou, Lun Kelvin, Chen, Jih-Jung, Wen, Zhi-Hong, Lo, Yi-Hao, Zheng, Li-Guo, Sung, Ping-Jyun
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Chemistry
Chlorine
Metabolites
NMR
Nuclear magnetic resonance
Single crystals
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Summary:The chemical screening of an octocoral identifed as has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra03062a