Predictors of in-hospital mortality in a cohort of people living with HIV (PLHIV) admitted to an academic medical intensive care unit from 2009 to 2014: A retrospective cohort study

• Published in: Medicine (Baltimore) 2022-07, Vol.101 (28), p.e29750-e29750
• Main Authors: Sowah, Leonard A., George, Nivya, Doll, Michelle, Chiou, Christine, Bhat, Pavan, Smith, Christopher, Palacio, Danica, Nieweld, Carl, Miller, Eric, Oni, Ibukunolupo, Okwesili, Christine, Mathur, Poonam, Saleeb, Paul G., Buchwald, Ulrike K.
• Format: Article
• Language: English
• Subjects: Cohort Studies; Critical Illness - therapy; HIV Infections - drug therapy; Hospital Mortality; Humans; Intensive Care Units; Observational Study; Retrospective Studies
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000029750

Outcomes for critically ill people living with human immunodeficiency virus (PLHIV) have changed with the use of antiretroviral therapy (ART). To identify these outcomes and correlates of mortality in a contemporary critically ill cohort in an urban academic medical center in Baltimore, a city with a high burden of HIV, we conducted a retrospective cohort study of individuals admitted to a medical intensive care unit (MICU) at a tertiary care center between 2009 and 2014. PLHIV who were at least 18 years of age with an index MICU admission of ≥24 hours during the 5-year study period were included in this analysis. Data were obtained for participants from the time of MICU admission until hospital discharge and up to 180 days after MICU admission. Logistic regression was used to identify independent predictors of hospital mortality. Between June 2009 and June 2014, 318 PLHIV admitted to the MICU met inclusion criteria. Eighty-six percent of the patients were non-Hispanic Blacks. Poorly controlled HIV was very common with 70.2% of patients having a CD4 cell count