Tissue damage from chronic liver injury inhibits peripheral NK cell abundance and proinflammatory function

One of the difficulties in the treatment of hepatocellular carcinoma is that it is impossible to eliminate the inhibitory effect of the tumor microenvironment on immune response. Therefore, it is particularly important to understand the formation process of the tumor microenvironment. Chronic inflam...

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Bibliographic Details
Published in:Journal of leukocyte biology 2024-05, Vol.115 (6), p.1042-1052
Main Authors: You, Zonghao, Ling, Shaoxue, Zhao, Shuwu, Han, Haixing, Bian, Yuhong, He, Yongzhi, Chen, Xi
Format: Article
Language:English
Subjects:
Animals
Chronic Disease
Humans
Inflammation - immunology
Inflammation - pathology
Killer Cells, Natural - immunology
Liver - immunology
Liver - pathology
Male
Tumor Microenvironment - immunology
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Summary:One of the difficulties in the treatment of hepatocellular carcinoma is that it is impossible to eliminate the inhibitory effect of the tumor microenvironment on immune response. Therefore, it is particularly important to understand the formation process of the tumor microenvironment. Chronic inflammation is the core factor of cancer occurrence and the leading stage of inflammation-cancer transformation, and the natural killer cell subsets play an important role in it. Our study confirmed that in the stage of chronic liver injury, the local immunosuppressive microenvironment of the liver (i.e. the damaged microenvironment) has been formed, but this inhibitory effect is only for peripheral natural killer cells and has no effect on tissue-resident natural killer subsets. The markers of damage microenvironment are the same as those of tumor microenvironment.
ISSN:1938-3673
0741-5400
1938-3673
DOI:10.1093/jleuko/qiae027