Novel estrogen receptor coregulators and signaling molecules in human diseases

The steroid hormone estrogen and signaling from its receptors are increasingly recognized as critical mediators of a variety of organ-specific biological processes. Recent advances in the identification and functional characterization of novel estrogen receptor interacting proteins clearly show the...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2004-02, Vol.61 (3), p.281-291
Main Authors: Barnes, C J, Vadlamudi, R K, Kumar, R
Format: Article
Language:English
Subjects:
Bone and Bones - physiology
Cardiovascular Physiological Phenomena
Chromatin - metabolism
Estrogens
Estrogens - metabolism
Humans
Neoplasms - metabolism
Neuroprotective Agents - metabolism
Nuclear Proteins - metabolism
Receptors, Estrogen - metabolism
Repressor Proteins - metabolism
Review
Signal Transduction - physiology
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Summary:The steroid hormone estrogen and signaling from its receptors are increasingly recognized as critical mediators of a variety of organ-specific biological processes. Recent advances in the identification and functional characterization of novel estrogen receptor interacting proteins clearly show the complexity of hormonal signaling regulation, but may also contribute to our understanding of the roles of estrogen signaling in normal physiology and the pathobiology of human disease.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-003-3222-5