Role of High Mobility Group Box 1 in Cardiovascular Diseases

High Mobility Group Box 1 (HMGB1) is a ubiquitous, highly conserved nuclear and cytosolic protein that has diverse biological roles depending on its cellular location and posttranslational modifications. The HMGB1 is localized in the nucleus but can be translocated to the cytoplasm to modulate the i...

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Bibliographic Details
Published in:Inflammation 2022-10, Vol.45 (5), p.1864-1874
Main Authors: Belmadani, Souad, Matrougui, Khalid
Format: Article
Language:English
Subjects:
Binding sites
Biomedical and Life Sciences
Biomedicine
Cardiomyopathy
Cardiovascular Diseases
Cell Nucleus - metabolism
Cytokines
Cytoplasm
Cytoplasm - metabolism
Dendritic cells
DNA methylation
Heart attacks
Heart failure
HMGB1 protein
HMGB1 Protein - metabolism
Humans
Hypoglycemia
Immunology
Inflammation
Inflammation - metabolism
Internal Medicine
Intracellular signalling
Ischemia
Kawasaki disease
Mobility
Myocarditis
Pathology
Pharmacology/Toxicology
Physiology
Proteins
Review
Rheumatology
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Description
Summary:High Mobility Group Box 1 (HMGB1) is a ubiquitous, highly conserved nuclear and cytosolic protein that has diverse biological roles depending on its cellular location and posttranslational modifications. The HMGB1 is localized in the nucleus but can be translocated to the cytoplasm to modulate the intracellular signaling and eventually secreted outside the cells. It is widely established that HMGB1 plays a key role in inflammation; however, the role of HMGB1 in the cardiovascular diseases is not well understood. In this review, we will discuss the latest reports on the pathophysiological link between HMGB1 and cardiovascular complications, with special emphasis on the inflammation. Thus, the understanding of the role of HMGB1 may provide new insights into developing new HMGB1-based therapies.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-022-01668-3