The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore

Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery can be divided into receptors that recognize preprotein targeting signals and components of t...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 1999-11, Vol.56 (9-10), p.817-824
Main Authors: Meisinger, C, Brix, J, Model, K, Pfanner, N, Ryan, M T
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - chemistry
Adenosine Triphosphatases - metabolism
Bacterial Proteins
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Cellular biology
Enzymes
Escherichia coli Proteins
Fungi - cytology
Fungi - enzymology
Fungi - metabolism
Intracellular Membranes - enzymology
Intracellular Membranes - metabolism
Macromolecular Substances
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Membrane Transport Proteins
Membranes
Mitochondria
Mitochondria - enzymology
Mitochondria - metabolism
Mitochondrial Precursor Protein Import Complex Proteins
nuclear pore complex
Permeability
preprotein translocase
Protein Subunits
Protein Transport
Proteins
SEC Translocation Channels
SecA Proteins
Translocation
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Summary:Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery can be divided into receptors that recognize preprotein targeting signals and components of the general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the central questions regarding the pore-forming subunits, and architecture and gating of the translocation channel of the outer membrane.
ISSN:1420-682X
1420-9071
DOI:10.1007/s000180050028