Anaplasma capra: a new emerging tick-borne zoonotic pathogen

• Published in: Veterinary research communications 2024-06, Vol.48 (3), p.1329-1340
• Main Authors: Altay, Kursat, Erol, Ufuk, Sahin, Omer Faruk
• Format: Article
• Language: English
• Subjects: Anaplasma - classification; Anaplasma - genetics; Anaplasma - isolation & purification; Anaplasma - pathogenicity; Anaplasma capra; Anaplasmosis; Anaplasmosis - epidemiology; Anaplasmosis - microbiology; Anaplasmosis - transmission; Animals; Arachnids; Biomedical and Life Sciences; Communicable Diseases, Emerging - epidemiology; Communicable Diseases, Emerging - microbiology; Communicable Diseases, Emerging - veterinary; Domestic animals; Genetic diversity; Genotype & phenotype; Genotypes; Goat Diseases - epidemiology; Goat Diseases - microbiology; Goats; Humans; Life Sciences; New species; Pathogenicity; Phylogeny; Review; Tick-Borne Diseases - epidemiology; Tick-Borne Diseases - microbiology; Tick-Borne Diseases - transmission; Tick-Borne Diseases - veterinary; Ticks - microbiology; Veterinary Medicine/Veterinary Science; Zoology; Zoonoses; Zoonoses - microbiology
• ISSN: 0165-7380; 1573-7446
• DOI: 10.1007/s11259-024-10337-9

The genus Anaplasma includes A. marginale, A. centrale, A. bovis, A. ovis, A. platys , and A. phagocytophilum transmitted by ticks, some of which are zoonotic and cause anaplasmosis in humans and animals. In 2012, a new species was discovered in goats in China. In 2015, the same agent was detected in humans in China, and it was provisionally named Anaplasma capra , referring to 2012. The studies conducted to date have revealed the existence of A. capra in humans, domestic animals, wild animals, and ticks from three different continents (Asia, Europe, and Africa). Phylogenetic analyses based on gltA and groEL sequences show that A. capra clearly includes two different genotypes ( A. capra genotype-1 and A. capra genotype-2). Although A. capra human isolates are in the genotype-2 group, goat, sheep, and cattle isolates are in both groups, making it difficult to establish a host genotype-relationship. According to current data, it can be thought that human isolates are genotype-2 and while only genotype-1 is found in Europe, both genotypes are found in Asia. Anaplasma capra causes clinical disease in humans, but the situation is not yet sufficient to understand the zoonotic importance and pathogenicity in animals. In the present review, the history, hosts (vertebrates and ticks), molecular prevalence, pathogenic properties, and genetic diversity of A. capra were evaluated from a broad perspective.