Probiotics supplementation in the treatment of male infertility: A Systematic Review

Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating th...

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Bibliographic Details
Published in:JBRA assisted reproduction 2024, Vol.28 (2), p.341-348
Main Authors: Oliveira, Licia Cristina Silva de Lima, Costa, Elton Carvalho, Martins, Fernanda Domingues Gomes, Rocha, Alcenir Sales da, Brasil, Girlandia Alexandre
Format: Article
Language:English
Subjects:
Antioxidants
Clinical trials
Fertility
Infertility
Microbiota
Morphology
Motility
Oxidative stress
Physiology
Probiotics
Reactive oxygen species
Review
Sperm
Systematic review
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Summary:Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents. Four randomized clinical studies met the inclusion criteria, focusing on men diagnosed with idiopathic male infertility (oligozoospermia, teratozoospermia, and asthenozoospermia). The findings revealed that probiotic administration exhibited promising antioxidant properties by combating reactive oxygen species (ROS), consequently protecting sperm DNA from damage that correlates with declining sperm quality. Significant improvements were observed across all sperm parameters, with notable enhancement in motility. Consequently, probiotic supplementation emerges as a potential therapeutic alternative for men diagnosed with idiopathic infertility, demonstrating positive effects on sperm quality.
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20240013