Moyamoya Disease: Advances in Diagnosis, Treatment, and Surgical Interventions

Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive narrowing of the brain's arteries, leading to an increased risk of stroke. The primary susceptibility gene, RNF213, has been identified in individuals of East Asian descent, contributing to ongoing research i...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-05, Vol.16 (5), p.e59826
Main Authors: Navandhar, Pratik S, Gharde, Pankaj, Shinde, Raju K, Nagtode, Tushar
Format: Article
Language:English
Subjects:
Atherosclerosis
Autoimmune diseases
Blood vessels
Brain cancer
Cardiac/Thoracic/Vascular Surgery
Cardiovascular disease
Carotid arteries
Congenital diseases
Coronary vessels
Down syndrome
General Surgery
Genetic disorders
Headaches
Hemodynamics
Hypertension
Hyperventilation
Ischemia
Medical diagnosis
Meningitis
Multiculturalism & pluralism
Neurosurgery
Stroke
Surgical techniques
Thyroid gland
Traumatic brain injury
Vein & artery diseases
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Summary:Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive narrowing of the brain's arteries, leading to an increased risk of stroke. The primary susceptibility gene, RNF213, has been identified in individuals of East Asian descent, contributing to ongoing research into potential therapeutic targets. The distinction between idiopathic MMD and secondary forms, such as Moyamoya syndrome (MMS), is discussed, focusing on associated conditions and risk factors. Surgical revascularization emerges as the mainstay of treatment, with direct, indirect, and combination bypass procedures explored. The review delves into advancements in imaging technology for diagnosis and treatment planning, emphasizing non-invasive magnetic resonance examination's role in identifying asymptomatic patients. Additionally, insights into anesthetic care and therapeutic approaches underscore the evolving understanding of this complex disease. The presented information aims to contribute to the ongoing dialogue surrounding MMD, providing a valuable resource for clinicians and researchers.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.59826