A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: Findings from the JACC study

The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40‐79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for...

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Bibliographic Details
Published in:Cancer science 2004-07, Vol.95 (7), p.602-607
Main Authors: Tamakoshi, Koji, Wakai, Kenji, Kojima, Masayo, Watanabe, Yoshiyuki, Hayakawa, Norihiko, Toyoshima, Hideaki, Yatsuya, Hiroshi, Kondo, Takaaki, Tokudome, Shinkan, Hashimoto, Shuji, Suzuki, Koji, Suzuki, Sadao, Kawado, Miyuki, Ozasa, Kotaro, Ito, Yoshinori, Tamakoshi, Akiko
Format: Article
Language:English
Subjects:
Abortion
Abortion, Induced
Adult
Age
Age Factors
Age of Onset
Aged
Biological and medical sciences
Cohort Studies
Colon cancer
Colonic Neoplasms - epidemiology
Colonic Neoplasms - etiology
Colorectal cancer
Etiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Health risk assessment
Humans
Japan - epidemiology
Life Style
Medical sciences
Menarche
Menopause
Menstruation
Middle Aged
Multivariate Analysis
Parity
Post-menopause
Postmenopause
Prospective Studies
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40‐79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow‐up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among pa‐rous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16‐2.55; trend P
ISSN:1347-9032
1349-7006
DOI:10.1111/j.1349-7006.2004.tb02494.x